Journal Article

DZNE-2026-00855

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Lymphocyte-derived microRNA hsa-miR-150-5p as a marker of inflammation-related kidney function impairment in the general population.

Van der Auwera, S. (First author)DZNE* ; Lange, T. ; Schmidt, T. ; Ameling, S. ; Friedrich, N. ; Nauck, M. ; Völker, U. ; Völzke, H. ; Endlich, N. ; Grabe, H. J. (Last author)DZNE*

2026
Elsevier San Diego, Calif.

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Please use a persistent id in citations: doi:10.1016/j.clim.2026.110752

Abstract: Previous studies have demonstrated strong links between circulating microRNAs (miRNA), lymphocytes, and immune markers suggesting that miRNAs are key regulators of immune function and immune related diseases. We used the population-based SHIP-TREND cohort (N = 804) to investigate how specific plasma-based miRNAs relate to lymphocytes, cardiometabolic diseases, and clinical parameters. In linear regression, we identified miR-150-5p to be strongly lymphocyte-associated in both TREND waves. Beyond this, miR-150-5p showed significant associations with kidney disease and also with several clinical markers of renal function. Data indicate that these effects mark the transition from healthy to subclinical disease status and were independent of lymphocytes. We further validated the impact of miR-150-5p in independent publically available clinical datasets. Our findings suggest that the pathological effects of lymphocytes on kidney disease may be mediated through miR-150-5p, by regulating the expression of target genes and modulating inflammatory pathways. This highlights miR-150-5p as a potential early marker of subclinical kidney disease.

Keyword(s): Biomarker ; Cardiometabolic diseases ; Kidney function ; Lymphocytes ; SHIP-TREND study ; miR-150-5p

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Contributing Institute(s):

1. Biomarkers of Dementia in the General Population (AG Grabe)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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