Journal Article

DZNE-2026-00902

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Anti-CD19 CAR T Cells in Autoimmune Encephalitis: Inflammation Controlled, Neurodegeneration Unchecked?

Mougiakakos, D. ; Al-Dubai, M. ; Walther, D. ; Borie, D. ; Lünemann, J. D. ; Pawlitzki, M. ; Meuth, S. G. ; Henneicke, S.DZNE* ; Vielhaber, S.Extern* ; Schreiber, S. (Last author)DZNE*

2026
Wiley Chichester [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1002/acn3.70414

Abstract: Just recently, successful chimeric antigen receptor (CAR) T cell therapy was reported in the first patient with refractory, anti-diacylglycerol lipase alpha (DAGLA) antibody-mediated autoimmune encephalitis, achieving partial clinical remission. We now provide extended follow-up demonstrating a stable, relapse-free clinical course and persistent suppression of autoantibodies. However, the patient exhibited progressive neurodegeneration despite sustained control of B cell-mediated inflammation. This dissociation between immune quiescence and structural decline highlights that CAR T cell therapy, while highly effective in extinguishing inflammation, may not be sufficient to prevent or reverse ongoing neuronal damage in disorders characterized by both inflammation and neurodegeneration.

Keyword(s): Humans (MeSH) ; Encephalitis: immunology (MeSH) ; Encephalitis: therapy (MeSH) ; Hashimoto Disease: therapy (MeSH) ; Hashimoto Disease: immunology (MeSH) ; Antigens, CD19: immunology (MeSH) ; Immunotherapy, Adoptive: methods (MeSH) ; T-Lymphocytes (MeSH) ; Inflammation: immunology (MeSH) ; Inflammation: therapy (MeSH) ; Neurodegenerative Diseases: immunology (MeSH) ; Neurodegenerative Diseases: therapy (MeSH) ; Female (MeSH) ; CAR T cells ; autoimmune encephalitis ; neurodegeneration ; Antigens, CD19

---

Contributing Institute(s):

1. Mixed Cerebral Pathologies and Cognitive Aging (AG Schreiber)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

---

Database coverage:
; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; DEAL Wiley ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---