Journal Article

DZNE-2026-01005

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Global Parkinson's Disease Genetics (GP2) Genome Browser.

Fang, Z.-H. (First author)DZNE* ; Grant, R. H. ; Vitale, D. ; Hernandez, C. F. ; Hong, S. ; Leonard, H. L. ; Makarious, M. B. ; Lange, L. M. ; Solomonson, M. ; Heutink, P. ; Dilliott, A. A. ; Galvelis, K. G. ; Nalls, M. A. ; Singleton, A. B. ; Blauwendraat, C. ; Program, G. P. G. (Collaboration Author)

2026
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mds.70309

Abstract: Large-scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease-causing variants, we developed an open-access, summary-level genomic data browser.We performed uniform joint variant calling to harmonize whole-genome sequencing (WGS) data from AMP-PD Release 4, GP2 Data Releases, and additional controls from the Alzheimer's Disease Sequencing Project. Clinical-exome sequencing (CES) data from GP2 Release 8 were also included.The integrated dataset included 31,665 WGS and 9,559 CES samples, spanning 11 ancestries and over 300 million variants.The GP2 Genome Browser is a lightweight, flexible platform providing intuitive gene- and variant-level summaries with ancestry-stratified allele frequencies and functional annotations. It is open source and freely accessible at https://gp2.broadinstitute.org, enabling broad access to PD genomic data and supporting global research efforts. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society. © 2026 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyword(s): Humans (MeSH) ; Parkinson Disease: genetics (MeSH) ; Whole Genome Sequencing (MeSH) ; Genetic Predisposition to Disease: genetics (MeSH) ; Databases, Genetic (MeSH) ; Genomics (MeSH) ; Web Browser (MeSH) ; Exome Sequencing (MeSH) ; Parkinson's disease ; browser ; genetics ; sequencing

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Contributing Institute(s):

1. Parkinson Genetics (AG Gasser)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2026

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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