Dataset

DZNE-2026-01086

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset: An intrinsic cytoskeletal oscillator establishes neuronal polarity, v1

Lin, T.-c.DZNE* ; Coles, C. ; Alfadil, E.DZNE* ; Fäßler, F. ; Husch, A.DZNE* ; Dupraz, S.Extern* ; Pietralla, T.DZNE* ; Narita, A. ; Schelski, M.Extern* ; Flynn, K.DZNE* ; Stern, S.DZNE* ; Möhl, C. ; Hilton, B. J. ; Vauti, F. ; Arnold, H.-H. ; Schur, F. ; Bradke, F.DZNE*

2026
Zenodo

This record in other databases:  

Please use a persistent id in citations: doi:10.5281/zenodo.20118606

Abstract: Data and analysis code accompanying the manuscript "An intrinsic cytoskeletal oscillator establishes neuronal polarity". The study shows that the neuronal soma acts as a central organiser of axon–dendrite polarity through a soma-initiated, Arp2/3-driven actin oscillator: periodic somatic actin waves remodel a global actomyosin network, transiently relax myosin-II contractility at a single neurite tip, and bias that neurite toward axon fate. Once stabilised by microtubules, the nascent axon escapes Arp2/3 dependence while sustained actomyosin activity keeps the remaining neurites as dendrites.

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Contributing Institute(s):

1. Axon Growth and Regeneration (AG Bradke)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Lin, T.-C. (First author)DZNE* ; Coles, C.DZNE* ; Alfadil, E.DZNE* ; Fäßler, F. ; Husch, A.DZNE* ; Dupraz, S.DZNE* ; Pietralla, T.DZNE* ; Narita, A. ; Schelski, M.DZNE* ; Flynn, K.DZNE* ; Stern, S.DZNE* ; Möhl, C.DZNE* ; Hilton, B. J. ; Vauti, F. ; Arnold, H.-H. ; Schur, F. K. M. ; Bradke, F. (Last author)DZNE*
An intrinsic cytoskeletal oscillator establishes neuronal polarity.
Nature 657(8130), 213 - 225 (2026) [10.1038/s41586-026-10755-6]2026   Files BibTeX | EndNote: XML, Text | RIS

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