Journal Article

DZNE-2020-02714

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Multicenter stability of diffusion tensor imaging measures: a European clinical and physical phantom study.

Teipel, S. J. (First author)DZNE* ; Reuter, S.DZNE* ; Stieltjes, B. ; Acosta-Cabronero, J. ; Ernemann, U. ; Fellgiebel, A. ; Filippi, M. ; Frisoni, G. ; Hentschel, F. ; Jessen, F. ; Klöppel, S. ; Meindl, T. ; Pouwels, P. J. W. ; Hauenstein, K.-H. ; Hampel, H.

2011
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.pscychresns.2011.05.012

Abstract: Diffusion tensor imaging (DTI) detects white matter damage in neuro-psychiatric disorders, but data on reliability of DTI measures across more than two scanners are still missing. In this study we assessed multicenter reproducibility of DTI acquisitions based on a physical phantom as well as brain scans across 16 scanners. In addition, we performed DTI scans in a group of 26 patients with clinically probable Alzheimer's disease (AD) and 12 healthy elderly controls at one single center. We determined the variability of fractional anisotropy (FA) measures using manually placed regions of interest as well as automated tract based spatial statistics and deformation based analysis. The coefficient of variation (CV) of FA was 6.9% for the physical phantom data. The mean CV across the multicenter brain scans was 14% for tract based statistics, and 29% for deformation based analysis. The degree of variation was higher in less organized fiber tracts. Our findings suggest that a clinical and physical phantom study involving more than two scanners is indispensable to detect potential sources of bias and to reliably estimate effect size in multicenter diagnostic trials using DTI.

Keyword(s): Aged (MeSH) ; Aged, 80 and over (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Anisotropy (MeSH) ; Bias (MeSH) ; Brain: pathology (MeSH) ; Brain Mapping (MeSH) ; Diffusion Tensor Imaging: methods (MeSH) ; Europe (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Middle Aged (MeSH) ; Nerve Fibers, Myelinated: pathology (MeSH) ; Phantoms, Imaging (MeSH) ; Young Adult (MeSH)

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Contributing Institute(s):

1. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2011

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