Journal Article

DZNE-2020-03599

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Transcriptome-based network analysis reveals a spectrum model of human macrophage activation.

Xue, J. ; Schmidt, S. V. ; Sander, J. ; Draffehn, A. ; Krebs, W. ; Quester, I. ; De Nardo, D. ; Gohel, T. D. ; Emde, M. ; Schmidleithner, L. ; Ganesan, H. ; Nino-Castro, A. ; Mallmann, M. R. ; Labzin, L. ; Theis, H. ; Kraut, M. ; Beyer, M. ; Latz, E.DZNE* ; Freeman, T. C. ; Ulas, T.Extern* ; Schultze, J. (Corresponding author)Extern*

2014
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.immuni.2014.01.006

Abstract: Macrophage activation is associated with profound transcriptional reprogramming. Although much progress has been made in the understanding of macrophage activation, polarization, and function, the transcriptional programs regulating these processes remain poorly characterized. We stimulated human macrophages with diverse activation signals, acquiring a data set of 299 macrophage transcriptomes. Analysis of this data set revealed a spectrum of macrophage activation states extending the current M1 versus M2-polarization model. Network analyses identified central transcriptional regulators associated with all macrophage activation complemented by regulators related to stimulus-specific programs. Applying these transcriptional programs to human alveolar macrophages from smokers and patients with chronic obstructive pulmonary disease (COPD) revealed an unexpected loss of inflammatory signatures in COPD patients. Finally, by integrating murine data from the ImmGen project we propose a refined, activation-independent core signature for human and murine macrophages. This resource serves as a framework for future research into regulation of macrophage activation in health and disease.

Keyword(s): Animals (MeSH) ; Cells, Cultured (MeSH) ; Gene Expression Profiling (MeSH) ; Humans (MeSH) ; Macrophage Activation: immunology (MeSH) ; Mice (MeSH) ; Models, Biological (MeSH) ; Transcriptome: genetics (MeSH)

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Contributing Institute(s):

1. Innate Immunity in Neurodegeneration (AG Latz ; AG Latz)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2014

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 15 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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