Journal Article

DZNE-2020-04552

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png CSF biomarkers for the differential diagnosis of Alzheimer's disease: A large-scale international multicenter study.

Ewers, M. (Corresponding author) ; Mattsson, N. ; Minthon, L. ; Molinuevo, J. L. ; Antonell, A. ; Popp, J. ; Jessen, F. ; Herukka, S.-K. ; Soininen, H. ; Maetzler, W.DZNE* ; Leyhe, T. ; Bürger, K. ; Taniguchi, M. ; Urakami, K. ; Lista, S. ; Dubois, B. ; Blennow, K. ; Hampel, H.

2015
Elsevier Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.jalz.2014.12.006

Abstract: The aim of this study was to test the diagnostic value of cerebrospinal fluid (CSF) beta-amyloid (Aβ1-42), phosphorylated tau, and total tau (tau) to discriminate Alzheimer's disease (AD) dementia from other forms of dementia.A total of 675 CSF samples collected at eight memory clinics were obtained from healthy controls, AD dementia, subjective memory impairment, mild cognitive impairment, vascular dementia, Lewy body dementia (LBD), fronto-temporal dementia (FTD), depression, or other neurological diseases.CSF Aβ1-42 showed the best diagnostic accuracy among the CSF biomarkers. At a sensitivity of 85%, the specificity to differentiate AD dementia against other diagnoses ranged from 42% (for LBD, 95% confidence interval or CI = 32-62) to 77% (for FTD, 95% CI = 62-90).CSF Aβ1-42 discriminates AD dementia from FTD, but shows significant overlap with other non-AD forms of dementia, possibly reflecting the underlying mixed pathologies.

Keyword(s): Aged (MeSH) ; Aged, 80 and over (MeSH) ; Alzheimer Disease: cerebrospinal fluid (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Amyloid beta-Peptides: cerebrospinal fluid (MeSH) ; Biomarkers: cerebrospinal fluid (MeSH) ; Diagnosis, Differential (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Internationality (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Peptide Fragments: cerebrospinal fluid (MeSH) ; Phosphorylation (MeSH) ; Sensitivity and Specificity (MeSH) ; Spinal Puncture (MeSH) ; tau Proteins: cerebrospinal fluid (MeSH) ; Amyloid beta-Peptides ; Biomarkers ; MAPT protein, human ; Peptide Fragments ; amyloid beta-protein (1-42) ; tau Proteins

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Contributing Institute(s):

1. Functional Neurogeriatrics (AG Maetzler)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2015

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Database coverage:
; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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