Journal Article (Review Article)

DZNE-2020-04638

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png EEG Radiotelemetry in Small Laboratory Rodents: A Powerful State-of-the Art Approach in Neuropsychiatric, Neurodegenerative, and Epilepsy Research.

Lundt, A. ; Wormuth, C. ; Siwek, M. E. ; Müller, R. ; Ehninger, D.DZNE* ; Henseler, C. ; Broich, K. ; Papazoglou, A. (Corresponding author) ; Weiergräber, M.

2016
Hindawi New York, NY

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Please use a persistent id in citations: doi:10.1155/2016/8213878

Abstract: EEG radiotelemetry plays an important role in the neurological characterization of transgenic mouse models of neuropsychiatric and neurodegenerative diseases as well as epilepsies providing valuable insights into underlying pathophysiological mechanisms and thereby facilitating the development of new translational approaches. We elaborate on the major advantages of nonrestraining EEG radiotelemetry in contrast to restraining procedures such as tethered systems or jacket systems containing recorders. Whereas a main disadvantage of the latter is their unphysiological, restraining character, telemetric EEG recording overcomes these disadvantages. It allows precise and highly sensitive measurement under various physiological and pathophysiological conditions. Here we present a detailed description of a straightforward successful, quick, and efficient technique for intraperitoneal as well as subcutaneous pouch implantation of a standard radiofrequency transmitter in mice and rats. We further present computerized 3D-stereotaxic placement of both epidural and deep intracerebral electrodes. Preoperative preparation of mice and rats, suitable anaesthesia, and postoperative treatment and pain management are described in detail. A special focus is on fields of application, technical and experimental pitfalls, and technical connections of commercially available radiotelemetry systems with other electrophysiological setups.

Keyword(s): Animals (MeSH) ; Brain: physiopathology (MeSH) ; Disease Models, Animal (MeSH) ; Electroencephalography: methods (MeSH) ; Epilepsy: physiopathology (MeSH) ; Mental Disorders: physiopathology (MeSH) ; Mice (MeSH) ; Neurodegenerative Diseases: physiopathology (MeSH) ; Rats (MeSH) ; Research (MeSH) ; Telemetry: methods (MeSH)

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Contributing Institute(s):

1. Translational Biogerontology (AG Ehninger)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Appears in the scientific report 2016

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Database coverage:
; ; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Ebsco Academic Search ; NCBI Molecular Biology Database ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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