Journal Article

DZNE-2020-06010

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Memory encoding-related anterior hippocampal potentials are modulated by deep brain stimulation of the entorhinal area.

Hansen, N. (Corresponding author) ; Chaieb, L. ; Derner, M. ; Hampel, K. G. ; Elger, C. E. ; Surges, R. ; Staresina, B. ; Axmacher, N.DZNE* ; Fell, J.

2018
Wiley New York, NY [u.a.]

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Please use a persistent id in citations: doi:10.1002/hipo.22808

Abstract: Deep brain stimulation (DBS) of the human entorhinal area using 50 Hz pulses has revealed conflicting results regarding memory performance. Moreover, its impact on memory-related hippocampal potentials has not yet been investigated.We recorded data from seven epilepsy patients implanted with depth electrodes in the entorhinal cortex, hippocampus, amygdala, and parahippocampal cortex. Entorhinal DBS (bipolar, biphasic 50 Hz pulses, on- and off-cycles of 15 s) was applied with low amplitude (0.1 mA) to resemble physiologic conditions. During DBS on- and off-periods, patients learned noun-color associations that were later tested.During entorhinal DBS we observed more positive deflections of event-related potentials (ranging from 700 to 950 ms) in the anterior hippocampus for the on- vs. off-condition. We detected no effects in the amygdala, mid hippocampus and parahippocampal cortex. On the behavioral level, no differences in memory performance (item and source memory) were apparent in the on- vs. off-condition, neither across all trials nor across patients.Our findings indicate that entorhinal DBS with low amplitude has an impact on memory encoding-related potentials within the anterior hippocampus, but not on memory performance per se.

Keyword(s): Adult (MeSH) ; Amygdala: physiology (MeSH) ; Amygdala: physiopathology (MeSH) ; Association Learning: physiology (MeSH) ; Deep Brain Stimulation: methods (MeSH) ; Entorhinal Cortex: physiology (MeSH) ; Entorhinal Cortex: physiopathology (MeSH) ; Epilepsy, Temporal Lobe: physiopathology (MeSH) ; Epilepsy, Temporal Lobe: psychology (MeSH) ; Epilepsy, Temporal Lobe: therapy (MeSH) ; Evoked Potentials (MeSH) ; Female (MeSH) ; Hippocampus: physiology (MeSH) ; Hippocampus: physiopathology (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Memory: physiology (MeSH)

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Contributing Institute(s):

1. Fehlfunktionen des Gedächtnisses (AG Axmacher)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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