Journal Article

DZNE-2020-06046

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity.

Mitroulis, I. (Corresponding author) ; Ruppova, K. ; Wang, B. ; Chen, L.-S. ; Grzybek, M. ; Grinenko, T. ; Eugster, A. ; Troullinaki, M. ; Palladini, A. ; Kourtzelis, I. ; Chatzigeorgiou, A. ; Schlitzer, A. ; Beyer, M.DZNE* ; Joosten, L. A. B. ; Isermann, B. ; Lesche, M. ; Petzold, A. ; Simons, K. ; Henry, I. ; Dahl, A. ; Schultze, J. L.DZNE* ; Wielockx, B. ; Zamboni, N. ; Mirtschink, P. ; Coskun, Ü. ; Hajishengallis, G. ; Netea, M. G. ; Chavakis, T.

2018
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.cell.2017.11.034

Abstract: Trained innate immunity fosters a sustained favorable response of myeloid cells to a secondary challenge, despite their short lifespan in circulation. We thus hypothesized that trained immunity acts via modulation of hematopoietic stem and progenitor cells (HSPCs). Administration of β-glucan (prototypical trained-immunity-inducing agonist) to mice induced expansion of progenitors of the myeloid lineage, which was associated with elevated signaling by innate immune mediators, such as IL-1β and granulocyte-macrophage colony-stimulating factor (GM-CSF), and with adaptations in glucose metabolism and cholesterol biosynthesis. The trained-immunity-related increase in myelopoiesis resulted in a beneficial response to secondary LPS challenge and protection from chemotherapy-induced myelosuppression in mice. Therefore, modulation of myeloid progenitors in the bone marrow is an integral component of trained immunity, which to date, was considered to involve functional changes of mature myeloid cells in the periphery.

Keyword(s): Animals (MeSH) ; Cells, Cultured (MeSH) ; Granulocyte-Macrophage Colony-Stimulating Factor: metabolism (MeSH) ; Immunity, Innate (MeSH) ; Immunologic Memory (MeSH) ; Interleukin-1beta: metabolism (MeSH) ; Male (MeSH) ; Mice (MeSH) ; Mice, Inbred C57BL (MeSH) ; Myeloid Progenitor Cells: drug effects (MeSH) ; Myeloid Progenitor Cells: immunology (MeSH) ; Myelopoiesis: immunology (MeSH) ; beta-Glucans: pharmacology (MeSH) ; Interleukin-1beta ; beta-Glucans ; Granulocyte-Macrophage Colony-Stimulating Factor

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Contributing Institute(s):

1. Platform for Single Cell Genomics and Epigenomics (PRECISE)
2. Clinical Single Cell Omics (CSCO) / Systems Medicine (AG Schultze)
3. Immunogenomics and Neurodegeneration (AG Beyer)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)
2. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)

Experiment(s):

1. Platform for Single Cell Genomics and Epigenomics at DZNE University of Bonn

Appears in the scientific report 2018

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 60 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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