Journal Article (Review Article)

DZNE-2020-07289

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Invited Review: The spectrum of age-related small vessel diseases: potential overlap and interactions of amyloid and nonamyloid vasculopathies.

Schreiber, S. (First author)DZNE* ; Willisch-Neumann, A.DZNE* ; Schreiber, F.DZNE* ; Assmann, A.DZNE* ; Scheumann, V. ; Perosa, V.DZNE* ; Jandke, S.DZNE* ; Mawrin, C. ; Carare, R. O. ; Werring, D. J.

2019
Wiley-Blackwell Oxford [u.a.]

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Please use a persistent id in citations: doi:10.1111/nan.12576

Abstract: Deep perforator arteriopathy (DPA) and cerebral amyloid angiopathy (CAA) are the commonest known cerebral small vessel diseases (CSVD), which cause ischaemic stroke, intracebral haemorrhage (ICH) and vascular cognitive impairment (VCI). While thus far mainly considered as separate entities, we here propose that DPA and CAA share similarities, overlap and interact, so that 'pure' DPA or CAA are extremes along a continuum of age-related small vessel pathologies. We suggest blood-brain barrier (BBB) breakdown, endothelial damage and impaired perivascular β-amyloid (Aβ) drainage are hallmark common mechanisms connecting DPA and CAA. We also suggest a need for new biomarkers (e.g. high-resolution imaging) to deepen understanding of the complex relationships between DPA and CAA.

Keyword(s): Aging: pathology (MeSH) ; Amyloid beta-Peptides: metabolism (MeSH) ; Animals (MeSH) ; Cerebral Small Vessel Diseases: pathology (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Male (MeSH)

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Contributing Institute(s):

1. U Clinical Researchers - Magdeburg (U Clinical Researchers - Magdeburg)
2. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)
2. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2019

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Database coverage:
; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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