Abstract/Journal Article

DZNE-2020-00751

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png E01: Modelling the trajectory of cortical atrophy in huntington’s disease

Johnson, E. B. ; Ziegler, G.DZNE* ; Penny, W. ; Rees, G. ; Tabrizi, S. J. ; Scahill, R. I. ; Gregory, S.

2018

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Please use a persistent id in citations: doi:10.1136/jnnp-2018-EHDN.95

Abstract: Background Despite histological evidence of widespread grey matter atrophy by end-stage Huntington’s disease (HD), the progression of cortical atrophy in HD has yet to be fully characterised.Aims Here, we aim to map cortical atrophy during the transition from premanifest to motor clinical diagnosis of manifest HD, modelling both non-linear and linear atrophy rates in a large cohort of participants, with MRI data spanning 6 years before and 5 years after clinical diagnosis.

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Contributing Institute(s):

1. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2018

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; National-Konsortium ; SCOPUS ; Web of Science Core Collection

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