Journal Article

DZNE-2021-00391

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Quantifying progression in primary progressive aphasia with structural neuroimaging.

Lombardi, J. ; Mayer, B. ; Semler, E. ; Anderl-Straub, S. ; Uttner, I. ; Kassubek, J.Extern* ; Diehl-Schmid, J. ; Danek, A. ; Levin, J.DZNE* ; Fassbender, K. ; Fließbach, K.DZNE* ; Schneider, A.DZNE* ; Huppertz, H.-J. ; Jahn, H. ; Volk, A. ; Kornhuber, J. ; Landwehrmeyer, B. ; Lauer, M. ; Prudlo, J.DZNE* ; Wiltfang, J. ; Schroeter, M. L. ; Ludolph, A. ; Otto, M. ; consortium, F. (Collaboration Author)

2021
Wiley Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/alz.12323

Abstract: The term primary progressive aphasia (PPA) sums up the non-fluent (nfv), the semantic (sv), and the logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry to monitor disease progression.Structural brain imaging and an extensive assessment were applied at baseline and up to 4-year(s) follow-up in 269 participants. With automated atlas-based volumetry 56 brain regions were assessed. Atrophy progression served to calculate sample sizes for therapeutic trials.At baseline highest atrophy appeared in parts of the left frontal lobe for nfvPPA (-17%) and of the left temporal lobe for svPPA (-34%) and lvPPA (-24%). Severest progression within 1-year follow-up occurred in the basal ganglia in nfvPPA (-7%), in the hippocampus/amygdala in svPPA (-9%), and in (medial) temporal regions in lvPPA (-6%).PPA presents as a left-dominant, mostly gray matter sensitive disease with considerable atrophy at baseline that proceeds variant-specific.

Keyword(s): Aged (MeSH) ; Aphasia, Primary Progressive: classification (MeSH) ; Aphasia, Primary Progressive: pathology (MeSH) ; Atrophy: pathology (MeSH) ; Brain: pathology (MeSH) ; Disease Progression (MeSH) ; Female (MeSH) ; Frontal Lobe: pathology (MeSH) ; Gray Matter: pathology (MeSH) ; Humans (MeSH) ; Image Processing, Computer-Assisted (MeSH) ; Longitudinal Studies (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Middle Aged (MeSH) ; Temporal Lobe: pathology (MeSH) ; atlas-based volumetry ; disease progression ; frontotemporal dementia ; longitudinal magnetic resonance imaging ; primary progressive aphasia ; sample size calculation

Note: (CC BY-NC)

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Contributing Institute(s):

1. Clinical Dementia Research München (Clinical Dementia Research München)
2. Patient studies (Patient studies, Bonn)
3. Clinical Dementia Research Bonn (Clinical Dementia Research Bonn)
4. Clinical Dementia Research Rostock /Greifswald (AG Teipel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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