Journal Article (Review Article)

DZNE-2021-00900

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png EEG measures for clinical research in major vascular cognitive impairment: recommendations by an expert panel.

Babiloni, C. ; Arakaki, X. ; Bonanni, L. ; Bujan, A. ; Carrillo, M. C. ; Del Percio, C. ; Edelmayer, R. M. ; Egan, G. ; Elahh, F. M. ; Evans, A. ; Ferri, R. ; Frisoni, G. B.Extern* ; Güntekin, B. ; Hainsworth, A. ; Hampel, H. ; Jelic, V. ; Jeong, J. ; Kim, D. K. ; Kramberger, M. ; Kumar, S. ; Lizio, R. ; Nobili, F. ; Noce, G. ; Puce, A. ; Ritter, P. ; Smit, D. J. A. ; Soricelli, A. ; Teipel, S.DZNE* ; Tucci, F. ; Sachdev, P. ; Valdes-Sosa, M. ; Valdes-Sosa, P. ; Vergallo, A. ; Yener, G.

2021
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.neurobiolaging.2021.03.003

Abstract: Vascular contribution to cognitive impairment (VCI) and dementia is related to etiologies that may affect the neurophysiological mechanisms regulating brain arousal and generating electroencephalographic (EEG) activity. A multidisciplinary expert panel reviewed the clinical literature and reached consensus about the EEG measures consistently found as abnormal in VCI patients with dementia. As compared to cognitively unimpaired individuals, those VCI patients showed (1) smaller amplitude of resting state alpha (8-12 Hz) rhythms dominant in posterior regions; (2) widespread increases in amplitude of delta (< 4 Hz) and theta (4-8 Hz) rhythms; and (3) delayed N200/P300 peak latencies in averaged event-related potentials, especially during the detection of auditory rare target stimuli requiring participants' responses in 'oddball' paradigms. The expert panel formulated the following recommendations: (1) the above EEG measures are not specific for VCI and should not be used for its diagnosis; (2) they may be considered as 'neural synchronization' biomarkers to enlighten the relationships between features of the VCI-related cerebrovascular lesions and abnormalities in neurophysiological brain mechanisms; and (3) they may be tested in future clinical trials as prognostic biomarkers and endpoints of interventions aimed at normalizing background brain excitability and vigilance in wakefulness.

Keyword(s): Brain: physiopathology (MeSH) ; Cognitive Dysfunction: diagnosis (MeSH) ; Cognitive Dysfunction: etiology (MeSH) ; Cognitive Dysfunction: physiopathology (MeSH) ; Dementia, Vascular: diagnosis (MeSH) ; Dementia, Vascular: etiology (MeSH) ; Dementia, Vascular: physiopathology (MeSH) ; Electroencephalography: methods (MeSH) ; Evoked Potentials: physiology (MeSH) ; Humans (MeSH) ; Rest: physiology (MeSH) ; Cerebrovascular disease (CVD) ; Event-related oscillations (EROs) ; Event-related potentials (ERPs) ; Resting state electroencephalographic (rsEEG) rhythms ; Small vessel disease ; Subcortical ischemic vascular disease ; Vascular cognitive impairment (VCI) ; Vascular contribution to cognitive impairment and dementia (VCID) ; Vascular dementia (VaD)

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Contributing Institute(s):

1. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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