Journal Article

DZNE-2021-01355

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Perceived and mentally rotated contents are differentially represented in cortical depth of V1.

Iamshchinina, P. ; Kaiser, D. ; Yakupov, R.DZNE* ; Haenelt, D. ; Sciarra, A. ; Mattern, H. ; Luesebrink, F. ; Düzel, E.DZNE* ; Speck, O.DZNE* ; Weiskopf, N. ; Cichy, R. M.

2021
Springer Nature London

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Please use a persistent id in citations: doi:10.1038/s42003-021-02582-4

Abstract: Primary visual cortex (V1) in humans is known to represent both veridically perceived external input and internally-generated contents underlying imagery and mental rotation. However, it is unknown how the brain keeps these contents separate thus avoiding a mixture of the perceived and the imagined which could lead to potentially detrimental consequences. Inspired by neuroanatomical studies showing that feedforward and feedback connections in V1 terminate in different cortical layers, we hypothesized that this anatomical compartmentalization underlies functional segregation of external and internally-generated visual contents, respectively. We used high-resolution layer-specific fMRI to test this hypothesis in a mental rotation task. We found that rotated contents were predominant at outer cortical depth bins (i.e. superficial and deep). At the same time perceived contents were represented stronger at the middle cortical bin. These results identify how through cortical depth compartmentalization V1 functionally segregates rather than confuses external from internally-generated visual contents. These results indicate that feedforward and feedback manifest in distinct subdivisions of the early visual cortex, thereby reflecting a general strategy for implementing multiple cognitive functions within a single brain region.

Keyword(s): Adult (MeSH) ; Female (MeSH) ; Humans (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Male (MeSH) ; Photic Stimulation (MeSH) ; Primary Visual Cortex: physiology (MeSH) ; Visual Perception: physiology (MeSH) ; Young Adult (MeSH)

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Contributing Institute(s):

1. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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