Journal Article (Review Article)

DZNE-2022-00123

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Polygenic Risk Scores Contribute to Personalized Medicine of Parkinson's Disease.

Dehestani, M.DZNE* ; Liu, H.DZNE* ; Gasser, T. (Last author)DZNE*

2021
MDPI Basel

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Please use a persistent id in citations: doi:10.3390/jpm11101030

Abstract: Parkinson's disease (PD) is the second most common neurodegenerative disorder characterized by the loss of dopaminergic neurons. The vast majority of PD patients develop the disease sporadically and it is assumed that the cause lies in polygenic and environmental components. The overall polygenic risk is the result of a large number of common low-risk variants discovered by large genome-wide association studies (GWAS). Polygenic risk scores (PRS), generated by compiling genome-wide significant variants, are a useful prognostic tool that quantifies the cumulative effect of genetic risk in a patient and in this way helps to identify high-risk patients. Although there are limitations to the construction and application of PRS, such as considerations of limited genetic underpinning of diseases explained by SNPs and generalizability of PRS to other populations, this personalized risk prediction could make a promising contribution to stratified medicine and tailored therapeutic interventions in the future.

Keyword(s): Parkinson’s disease ; personalized medicine ; polygenic risk scores

Note: CC BY

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Contributing Institute(s):

1. Parkinson Genetics (AG Gasser)
2. Tübingen common (Tübingen common)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2021

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