Journal Article

DZNE-2022-00350

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Characteristics of subjective cognitive decline associated with amyloid positivity.

Janssen, O. ; Jansen, W. J. ; Vos, S. J. B. ; Boada, M. ; Parnetti, L. ; Gabryelewicz, T. ; Fladby, T. ; Molinuevo, J. L. ; Villeneuve, S. ; Hort, J. ; Epelbaum, S. ; Lleó, A. ; Engelborghs, S. ; van der Flier, W. M. ; Landau, S. ; Popp, J. ; Wallin, A. ; Scheltens, P. ; Rikkert, M. O. ; Snyder, P. J. ; Rowe, C. ; Chételat, G. ; Ruíz, A. ; Marquié, M. ; Chipi, E. ; Wolfsgruber, S.DZNE* ; Heneka, M.Extern* ; Boecker, H.Extern* ; Peters, O.Extern* ; Jarholm, J. ; Rami, L. ; Tort-Merino, A. ; Binette, A. P. ; Poirier, J. ; Rosa-Neto, P. ; Cerman, J. ; Dubois, B. ; Teichmann, M. ; Alcolea, D. ; Fortea, J. ; Sánchez-Saudinós, M. B. ; Ebenau, J. ; Pocnet, C. ; Eckerström, M. ; Thompson, L. ; Villemagne, V. ; Buckley, R. ; Burnham, S. ; Delarue, M. ; Freund-Levi, Y. ; Wallin, Å. K. ; Ramakers, I. ; Tsolaki, M. ; Soininen, H. ; Hampel, H. ; Spiru, L. ; Initiative, A. D. N. (Collaboration Author) ; group, F. s. (Collaboration Author) ; group, P. r. (Collaboration Author) ; Tijms, B. ; Ossenkoppele, R. ; Verhey, F. R. J. ; Jessen, F.DZNE* ; Visser, P. J.

2022
Wiley Hoboken, NJ

This record in other databases:    

Please use a persistent id in citations: doi:10.1002/alz.12512

Abstract: The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited.In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) ε4 carriership, and neuropsychiatric symptoms with amyloid positivity.Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE ε4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages.Next to age, setting, and APOE ε4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.

Keyword(s): Humans (MeSH) ; Amyloid (MeSH) ; Amyloidogenic Proteins (MeSH) ; Amyloidosis (MeSH) ; Apolipoprotein E4: genetics (MeSH) ; Biomarkers (MeSH) ; Brain: metabolism (MeSH) ; Cognitive Dysfunction: genetics (MeSH) ; Cognitive Dysfunction: psychology (MeSH) ; Positron-Emission Tomography (MeSH) ; Alzheimer's disease ; amyloid ; cerebrospinal fluid ; positron emission tomography ; subjective cognitive decline

Note: (CC BY-NC)

---

Contributing Institute(s):

1. Neuropsychology (AG Wagner)
2. Clinical Alzheimer’s Disease Research (AG Jessen)
3. Delcode (Delcode)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Experiment(s):

1. Longitudinal Cognitive Impairment and Dementia Study

Appears in the scientific report 2022

---

Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Wiley ; Essential Science Indicators ; IF >= 15 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---