Journal Article (Review Article)

DZNE-2022-00398

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Animal models of brain-first and body-first Parkinson's disease.

Van Den Berge, N. ; Ulusoy, A. (Last author)DZNE*

2022
Academic Press Orlando, Fla.

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Please use a persistent id in citations: doi:10.1016/j.nbd.2021.105599

Abstract: Alpha-synuclein aggregates are the hallmark pathology of Parkinson's disease, which can propagate in a stereotypical pattern along the brain-body axis. Parkinson's disease patients not only display heterogeneous symptoms but also show variable patterns of alpha-synuclein pathology and affected neuronal systems during the disease course, complicating early and accurate diagnosis. Emerging data from post-mortem and imaging studies strongly suggest that disease heterogeneity could, at least in part, be explained by variable disease onset site, i.e. brain or body. This has led to the recently hypothesized formulation of two Parkinson's disease-subtypes, a body-first subtype where pathogenic alpha-synuclein arises in the body and spreads to the brain, and a brain-first subtype where pathogenic alpha-synuclein arises in the brain and spreads to the body. From a preclinical perspective, several animal models have been adapted or developed to reproduce Parkinson's disease-like pathology in the brain or periphery aiming to address the site of disease onset. Here, we review the current rodent and primate models that aim to reproduce Parkinson's disease pathology development and spreading in the brain and/or body and discuss the value and shortcomings of these models for the development of potential future applications in clinical trials and personalized medicine.

Keyword(s): Animals (MeSH) ; Brain: metabolism (MeSH) ; Brain: physiopathology (MeSH) ; Disease Models, Animal (MeSH) ; Parkinson Disease: metabolism (MeSH) ; Parkinson Disease: physiopathology (MeSH) ; alpha-Synuclein: metabolism (MeSH) ; Alpha-synuclein ; Animal models ; Parkinson's disease subtypes ; Seeding ; alpha-Synuclein

Note: (CC BY-NC-ND)

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Contributing Institute(s):

1. Neurodegeneration and Neuroprotection in Parkinson´s Disease (AG Di Monte)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2022

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Database coverage:
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