Journal Article

DZNE-2022-00655

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Serum Beta-Synuclein Is Higher in Down Syndrome and Precedes Rise of pTau181.

Oeckl, P. (First author)DZNE* ; Wagemann, O.DZNE* ; Halbgebauer, S.Extern* ; Anderl-Straub, S. ; Nuebling, G. S. O.DZNE* ; Prix, C.Extern* ; Loosli, S. V. ; Wlasich, E. ; Danek, A.Extern* ; Steinacker, P. ; Ludolph, A. C.DZNE* ; Levin, J.DZNE* ; Otto, M.

2022
Wiley-Blackwell Hoboken, NJ

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Please use a persistent id in citations: doi:10.1002/ana.26360

Abstract: This exploratory case-control study investigates the synaptic marker beta-synuclein in serum and plasma pTau181 in adults with Down syndrome (DS) with (sDS, n = 14) and without (aDS, n = 47) clinical symptoms of Alzheimer disease (AD) as well as euploid controls (n = 23). Beta-synuclein was higher in aDS and more pronounced in sDS (p < 0.0001), whereas pTau181 was only higher in sDS (p < 0.0001). Both markers showed good discriminatory power (area under the curve > 0.90) to distinguish symptomatic from asymptomatic AD. The data indicate that synaptic alterations belong to the earliest AD-associated events in DS and highlight the value of serum beta-synuclein as a potential early marker of AD. ANN NEUROL 2022.

Keyword(s): Adult (MeSH) ; Alzheimer Disease: diagnosis (MeSH) ; Amyloid beta-Peptides (MeSH) ; Biomarkers (MeSH) ; Case-Control Studies (MeSH) ; Down Syndrome (MeSH) ; Humans (MeSH) ; beta-Synuclein (MeSH) ; tau Proteins (MeSH)

Note: (CC BY-NC-ND)

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Contributing Institute(s):

1. Translational Mass Spectrometry and Biomarker Research (AG Öckl)
2. Clinical Dementia Research München (Clinical Dementia Research München)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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