Journal Article

DZNE-2022-00710

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png O-LM interneurons: Gatekeepers of pyramidal neuron activity in the hippocampus.

Poll, S. (First author)DZNE* ; Fuhrmann, M. (Last author)DZNE*

2022
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.neuron.2022.04.022  doi:10.60944/dzne-2022-00710

Abstract: A balanced and fine-tuned ratio of neuronal excitation and inhibition is a prerequisite for information processing. In this issue of Neuron, He et al. (2022) reveal a causal link between reduced input to local somatostatin-expressing, MeCP2-negative O-LM interneurons in CA1 and long-term memory impairment in a mouse model of Rett syndrome.

Keyword(s): Animals (MeSH) ; Hippocampus (MeSH) ; Interneurons: physiology (MeSH) ; Mice (MeSH) ; Pyramidal Cells: physiology (MeSH) ; Rett Syndrome (MeSH) ; Animals ; Hippocampus ; Interneurons: physiology ; Mice ; Pyramidal Cells: physiology ; Rett Syndrome ; MeCP2 ; E/I imbalance ; O-LM interneurons ; somatostatin-expressing interneurons ; CA1 ; long-term memory impairment

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Contributing Institute(s):

1. Neuroimmunology and Imaging (AG Fuhrmann)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2022

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Database coverage:
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