Journal Article (Review Article)

DZNE-2022-01534

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png How location and cellular signaling combine to activate the NLRP3 inflammasome.

Akbal, A. ; Dernst, A. ; Lovotti, M.Extern* ; Mangan, M. S. J.Extern* ; McManus, R. M.DZNE* ; Latz, E. (Last author)DZNE*

2022
Nature Publ. Group London [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1038/s41423-022-00922-w

Abstract: NOD-, LRR-, and pyrin domain-containing 3 (NLRP3) is a cytosolic innate immune sensor of cellular stress signals, triggered by infection and sterile inflammation. Upon detection of an activating stimulus, NLRP3 transitions from an inactive homo-oligomeric multimer into an active multimeric inflammasome, which promotes the helical oligomeric assembly of the adaptor molecule ASC. ASC oligomers provide a platform for caspase-1 activation, leading to the proteolytic cleavage and activation of proinflammatory cytokines in the IL-1 family and gasdermin D, which can induce a lytic form of cell death. Recent studies investigating both the cellular requirement for NLRP3 activation and the structure of NLRP3 have revealed the complex regulation of NLRP3 and the multiple steps involved in its activation. This review presents a perspective on the biochemical and cellular processes controlling the assembly of the NLRP3 inflammasome with particular emphasis on structural regulation and the role of organelles. We also highlight the latest research on metabolic control of this inflammatory pathway and discuss promising clinical targets for intervention.

Keyword(s): Humans (MeSH) ; Inflammasomes: metabolism (MeSH) ; NLR Family, Pyrin Domain-Containing 3 Protein: metabolism (MeSH) ; Cytokines: metabolism (MeSH) ; Inflammation (MeSH) ; Interleukin-1beta: metabolism (MeSH) ; Inflammasome ; Localization ; Mechanism ; NLRP3 ; Regulation ; Structure

Note: CC BY: https://creativecommons.org/licenses/by/4.0/

---

Contributing Institute(s):

1. Innate Immunity in Neurodegeneration (AG Latz ; AG Latz)
2. Neuroinflammation, Biomarker (AG Heneka ; AG Heneka)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)
2. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

---

Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Essential Science Indicators ; IF >= 20 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---