Dataset

DZNE-2022-01789

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset: Data from: Metformin reverses early cortical network dysfunction and behavior changes in Huntington’s disease

Arnoux, I. ; Willam, M. ; Griesche, N.DZNE* ; Krummeich, J.Extern* ; Watari, H. ; Offermann, N.DZNE* ; Weber, S.DZNE* ; Narayan Dey, P. ; Chen, C. ; Monteiro, O. ; Buettner, S.DZNE* ; Meyer, K.DZNE* ; Bano, D.DZNE* ; Radyushkin, K. ; Langston, R. ; Lambert, J. J.DZNE* ; Wanker, E. ; Methner, A. ; Krauss, S.DZNE* ; Schweiger, S. ; Stroh, A.

2018
Dryad

This record in other databases:

Please use a persistent id in citations: doi:10.5061/dryad.g3b5272  doi:10.5061/DRYAD.G3B5272

Abstract: Catching primal functional changes in early, “very far from disease onset” (VFDO) stages of Huntington’s disease is likely to be the key to a successful therapy. Focusing on VFDO stages, we assessed neuronal microcircuits in premanifest Hdh150 knock-in mice. Employing in vivo two-photon Ca2+ imaging, we revealed an early pattern of circuit dysregulation in the visual cortex- one of the first regions affected in premanifest Huntington’s disease - characterized by an increase in activity, an enhanced synchronicity and hyperactive neurons. These findings are accompanied by aberrations in animal behavior. We furthermore show that the anti-diabetic drug metformin diminishes aberrant Huntingtin protein load and fully restores both, early network activity patterns and behavioral aberrations. This network-centered approach reveals a critical window of vulnerability far before clinical manifestation and establishes metformin as a promising candidate for a chronic therapy starting early in premanifest Huntington’s disease pathogenesis long before the onset of clinical symptoms.

Keyword(s): cortical microcircuits ; Huntington disease ; in vivo calcium imaging ; metformin ; neuronal hyperactivity

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Contributing Institute(s):

1. Regulatory RNA-protein interaction in neurodegenerative diseases (AG Krauß)
2. Aging and Neurodegeneration (AG Bano)
3. Immune Regulation (AG Capasso)
4. Biorepository (Biorepository)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)
2. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2018

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Arnoux, I. ; Willam, M. ; Griesche, N.DZNE* ; Krummeich, J. ; Watari, H. ; Offermann, N.DZNE* ; Weber, S.DZNE* ; Narayan Dey, P. ; Chen, C. ; Monteiro, O. ; Büttner, S.DZNE* ; Meyer, K.DZNE* ; Bano, D.DZNE* ; Radyushkin, K. ; Langston, R. ; Lambert, J. J. ; Wanker, E. ; Methner, A. ; Krauß, S. (Corresponding author)DZNE* ; Schweiger, S. ; Stroh, A.
Metformin reverses early cortical network dysfunction and behavior changes in Huntington's disease.
eLife 7, e38744 (2018) [10.7554/eLife.38744]2018   Files  Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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