Journal Article (Review Article)

DZNE-2023-00197

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Phase Separation in Biology and Disease; Current Perspectives and Open Questions.

Boeynaems, S. ; Chong, S. ; Gsponer, J. ; Holt, L. ; Milovanovic, D.DZNE* ; Mitrea, D. M. ; Mueller-Cajar, O. ; Portz, B. ; Reilly, J. F. ; Reinkemeier, C. D. ; Sabari, B. R. ; Sanulli, S. ; Shorter, J. ; Sontag, E. ; Strader, L. ; Stachowiak, J. ; Weber, S. C. ; White, M. ; Zhang, H. ; Zweckstetter, M.DZNE* ; Elbaum-Garfinkle, S. ; Kriwacki, R.

2023
Elsevier Amsterdam [u.a.]

This record in other databases:    

Please use a persistent id in citations: doi:10.1016/j.jmb.2023.167971

Abstract: In the past almost 15 years, we witnessed the birth of a new scientific field focused on the existence, formation, biological functions, and disease associations of membraneless bodies in cells, now referred to as biomolecular condensates. Pioneering studies from several laboratories [reviewed in1-3] supported a model wherein biomolecular condensates associated with diverse biological processes form through the process of phase separation. These and other findings that followed have revolutionized our understanding of how biomolecules are organized in space and time within cells to perform myriad biological functions, including cell fate determination, signal transduction, endocytosis, regulation of gene expression and protein translation, and regulation of RNA metabolism. Further, condensates formed through aberrant phase transitions have been associated with numerous human diseases, prominently including neurodegeneration and cancer. While in some cases, rigorous evidence supports links between formation of biomolecular condensates through phase separation and biological functions, in many others such links are less robustly supported, which has led to rightful scrutiny of the generality of the roles of phase separation in biology and disease.4-7 During a week-long workshop in March 2022 at the Telluride Science Research Center (TSRC) in Telluride, Colorado, ∼25 scientists addressed key questions surrounding the biomolecular condensates field. Herein, we present insights gained through these discussions, addressing topics including, roles of condensates in diverse biological processes and systems, and normal and disease cell states, their applications to synthetic biology, and the potential for therapeutically targeting biomolecular condensates.

Keyword(s): Humans (MeSH) ; Phase Transition (MeSH) ; Disease (MeSH) ; Biomolecular Condensates (MeSH) ; biomolecular condensates ; membraneless organelles ; phase separation

Note: LIC: CCBY4

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Contributing Institute(s):

1. Molecular Neurobiology (AG Milovanovic)
2. Structural Biology in Dementia (AG Zweckstetter)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)
2. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2023

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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