Journal Article

DZNE-2023-00760

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Longitudinal Studies on Alzheimer Disease Mouse Models with Multiple Tracer PET/CT: Application of Reduction and Refinement Principles in Daily Practice to Safeguard Animal Welfare during Progressive Aging.

Palumbo, G. ; Kunze, L. H.DZNE* ; Oos, R. ; Wind-Mark, K.DZNE* ; Lindner, S. ; von Ungern-Sternberg, B. ; Bartenstein, P. ; Ziegler, S. ; Brendel, M. (Last author)DZNE*

2023
MDPI Basel

This record in other databases:    

Please use a persistent id in citations: doi:10.3390/ani13111812

Abstract: Longitudinal studies on mouse models related to Alzheimer disease (AD) pathology play an important role in the investigation of therapeutic targets to help pharmaceutical research in the development of new drugs and in the attempt of an early diagnosis that can contribute to improving people's quality of life. There are several advantages to enriching longitudinal studies in AD models with Positron Emission Tomography (PET); among these advantages, the possibility of following the principle of the 3Rs of animal welfare is fundamental. In this manuscript, good daily experimental practice focusing on animal welfare is described and commented upon, based on the experience attained from studies conducted in our Nuclear Medicine department.

Keyword(s): Alzheimer disease ; enrichment environment ; longitudinal study ; reduction ; refinement ; small animal positron emission tomography

---

Contributing Institute(s):

1. Molecular Neurodegeneration (AG Haass)
2. Translational Brain Research (AG Herms)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2023

---

Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

---