Journal Article

DZNE-2023-01106

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The Impact of Sex-Specific Survival on the Incidence of Dementia in Parkinson's Disease.

Fink, A. (First author)DZNE* ; Dodel, R. ; Georges, D. ; Doblhammer-Reiter, G. (Last author)DZNE*

2023
Wiley New York, NY

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Please use a persistent id in citations: doi:10.1002/mds.29596

Abstract: The aim of our study is to analyze sex-specific patterns of Parkinson's disease dementia (PDD) incidence. We are investigating the extent to which sex differences in survival after initial Parkinson's disease (PD) diagnosis influence differences in PDD risk among PD patients.We used a random sample of German longitudinal health claims data of persons ages 50+ (2004-2019; n = 250,000) and identified new PD cases ages 65+ who were followed-up for a PDD diagnosis or death between 2006 and 2017. We performed Cox and competing-risk regression models, with death as competing event, to calculate PDD hazard ratios (HR) adjusted for age at PD onset, PD severity as measured by the modified Hoehn and Yahr (HY) scale, comorbidities, and medications.Of 2195 new PD cases, 602 people died before PDD and 750 people developed PDD by the end of 2017. The adjusted risk of PDD differs by sex, with men having a higher PDD risk than women. When accounting for death, men and women do not differ in their PDD risk (HR = 1.02, P = 0.770). Sex-specific analyses showed significant age and severity effects in women (age: HR = 1.05, P < 0.001; HY 3-5 vs. 0-2.5: HR = 1.46, P = 0.011), but not in men.Older age at first PD diagnosis and higher disease severity increase PDD risk, but this association is attenuated for PD men when controlling for death. This implies that the most frail PD men die rapidly before receiving a dementia diagnosis, whereas women with PD survive at higher rates, regardless of their age at onset and disease severity. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyword(s): Humans (MeSH) ; Female (MeSH) ; Male (MeSH) ; Parkinson Disease: complications (MeSH) ; Parkinson Disease: epidemiology (MeSH) ; Parkinson Disease: diagnosis (MeSH) ; Dementia: etiology (MeSH) ; Incidence (MeSH) ; Alzheimer Disease: complications (MeSH) ; Parkinson's disease ; Parkinson's disease dementia ; competing-risk ; epidemiology ; sex

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Contributing Institute(s):

1. Demographic Studies (AG Doblhammer)

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)

Appears in the scientific report 2023

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Database coverage:
; ; ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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