Journal Article (Review Article)

DZNE-2024-01153

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Neuronal maturation and axon regeneration: unfixing circuitry to enable repair.

Hilton, B. J. ; Griffin, J.DZNE* ; Fawcett, J. W. ; Bradke, F. (Last author)DZNE*

2024
Nature Publ. Group London

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Please use a persistent id in citations: doi:10.1038/s41583-024-00849-3

Abstract: Mammalian neurons lose the ability to regenerate their central nervous system axons as they mature during embryonic or early postnatal development. Neuronal maturation requires a transformation from a situation in which neuronal components grow and assemble to one in which these components are fixed and involved in the machinery for effective information transmission and computation. To regenerate after injury, neurons need to overcome this fixed state to reactivate their growth programme. A variety of intracellular processes involved in initiating or sustaining neuronal maturation, including the regulation of gene expression, cytoskeletal restructuring and shifts in intracellular trafficking, have been shown to prevent axon regeneration. Understanding these processes will contribute to the identification of targets to promote repair after injury or disease.

Keyword(s): Animals (MeSH) ; Nerve Regeneration: physiology (MeSH) ; Axons: physiology (MeSH) ; Humans (MeSH) ; Neurogenesis: physiology (MeSH) ; Neurons: physiology (MeSH)

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Contributing Institute(s):

1. Axon Growth and Regeneration (AG Bradke)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2024

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; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Nature ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 30 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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