Dataset

DZNE-2025-00825

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset: GBA1 interactome for understanding pathological mechanisms

Stein, F. ; Deleidi, M.DZNE*

2023
PRoteomics IDEntifications Database

Abstract: Compound heterozygous or homozygous GBA1 mutations lead to Gaucher disease. Furthermore, GBA1 mutations are the most frequent risk factor for Parkinson's disease. To get a better understanding of the pathological mechanisms, we generated inducible V5-Flag-Tag, V5-Flag-tagged WT, E326K and L444P mutant Flp-Inâ„¢T-RExâ„¢-HEK293 and performed interatomic analysis.

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Contributing Institute(s):

1. Mitochondria and Inflammation in Neurodegenerative Diseases (AG Deleidi)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Baden, P. (First author)DZNE* ; Perez, M. J. (First author)DZNE* ; Raji, H.DZNE* ; Bertoli, F.DZNE* ; Kalb, S.DZNE* ; Illescas, M. ; Spanos, F.DZNE* ; Giuliano, C.DZNE* ; Calogero, A. M. ; Oldrati, M.DZNE* ; Hebestreit, H.DZNE* ; Cappelletti, G. ; Brockmann, K.DZNE* ; Gasser, T.DZNE* ; Schapira, A. H. V. ; Ugalde, C. ; Deleidi, M. (Last author)DZNE*
Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism.
Nature Communications 14(1), 1930 (2023) [10.1038/s41467-023-37454-4]2023   Files  Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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