Journal Article (Review Article)

DZNE-2025-01025

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Arterial stiffness and vascular aging: mechanisms, prevention, and therapy.

Herzog, M. J. ; Müller, P. (First author)DZNE* ; Lechner, K. ; Stiebler, M.Extern* ; Arndt, P.DZNE* ; Kunz, M. ; Ahrens, D. ; Schmeißer, A. ; Schreiber, S.DZNE* ; Braun-Dullaeus, R. C.

2025
Macmillan Publishers, part of Springer Nature London

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Please use a persistent id in citations: doi:10.1038/s41392-025-02346-0

Abstract: Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. The central underlying mechanisms of cardiovascular diseases are vascular aging and associated arterial stiffness. Arterial stiffness is characterized by structural (e.g., tunica media calcification, alterations in vascular smooth muscle cells, and fibrosis) and functional (e.g., loss of Windkessel function, elevated pulse pressure, and development of isolated systolic hypertension) vascular changes that cause microvascular dysfunction and end-organ damage (e.g., heart failure, vascular dementia, hypertensive retinopathy, and chronic kidney disease). Current research indicates that arterial stiffness is an independent risk factor for cardiovascular diseases and represents a potential target for personalized prevention and therapeutic approaches. In this review, we summarize the pathophysiological mechanisms of vascular aging and arterial stiffness, outline the resulting end-organ damage, present different methods for the measurement of arterial stiffness, highlight the potential role of prevention and therapy, and provide future perspectives for arterial stiffness research. The purpose of this review is to provide a state-of-the-art interdisciplinary and translational approach to arterial stiffness, highlighting unique pathophysiological mechanisms (e.g., perivascular adipose tissue, extracellular vesicles), clinical relevance, and future directions.

Keyword(s): Humans (MeSH) ; Vascular Stiffness: genetics (MeSH) ; Aging: pathology (MeSH) ; Cardiovascular Diseases: physiopathology (MeSH) ; Cardiovascular Diseases: therapy (MeSH) ; Cardiovascular Diseases: prevention & control (MeSH) ; Cardiovascular Diseases: pathology (MeSH) ; Muscle, Smooth, Vascular: pathology (MeSH) ; Muscle, Smooth, Vascular: metabolism (MeSH) ; Muscle, Smooth, Vascular: physiopathology (MeSH) ; Animals (MeSH)

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Contributing Institute(s):

1. Neuroprotection (AG Müller)
2. Mixed Cerebral Pathologies and Cognitive Aging (AG Schreiber)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2025

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Database coverage:
; ; ; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 30 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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