Journal Article

DZNE-2026-00144

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Effects of lifestyle intervention and supplementation with insoluble oat fiber on cognitive functions in patients with prediabetes: a secondary analysis of the Optimal Fiber Trial.

Kabisch, S. ; Montagna, F. ; Honsek, C. ; Kemper, M. ; Gerbracht, C. ; Arafat, A. M. ; Birkenfeld, A. L. ; Dambeck, U. ; Osterhoff, M. A. ; Weickert, M. O. ; Flöel, A.DZNE* ; Pfeiffer, A. F. H.

2026
Frontiers Media Lausanne

This record in other databases:    

Please use a persistent id in citations: doi:10.3389/fnut.2025.1699958

Abstract: In cohort studies, intake of insoluble cereal fiber is associated with multiple health benefits, including preserved cognitive functions. However, evidence from intervention studies is sparse. In the Optimal Fiber Trial (OptiFiT), lifestyle changes and supplementation with oat fiber in prediabetes patients improved glycemic metabolism and body composition, which could be linked to cognitive changes.In OptiFiT, 180 patients with impaired glucose tolerance received either an insoluble fiber supplement or a placebo for 2 years in a double-blind, randomized approach, and underwent a parallel 1-year complex lifestyle intervention program. Annual visits included metabolic, anthropometric, and cognitive assessments: Mini-Mental State Examination (MMSE), Verbal Learning Memory Test (VLMT), Regensburg Word Fluency Test (RWFT), Number Connection Test (NCT), Number Recall Test (NRT), and Rey-Osterrieth Complex Figure Test (RCFT). Group-wise comparisons were conducted both globally as well as stratified by age.Cognitive functions only slightly improved-particularly in VLMT and RWFT-without major differences by group or age. At baseline, cognitive function measured by RCFT recall, VLMT, RWFT, and backwards NRT was inversely correlated with age, but not with HbA1c, fasting, or postprandial glucose levels.Beneficial effects of insoluble fiber and lifestyle intervention on glycemia might not translate into preserved cognitive capabilities in middle-to-higher aged patients with prediabetes in a 2-year intervention period. Long-term intervention studies in patients with both cognitive vulnerability and metabolic susceptibility are warranted. Such large RCTs should also corroborate putatively involved mechanisms in the epidemiologically assumed protection from cognitive decline.Clinicaltrials.gov, identifier NCT01681173.

Keyword(s): cognition ; diabetes prevention ; impaired glucose tolerance ; insoluble fiber ; learning ; memory ; prediabetes ; type 2 diabetes

---

Contributing Institute(s):

1. Dementia Prevention – Mechanisms and Clinical Implementation (AG Flöel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2026

---

Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Essential Science Indicators ; Fees ; IF >= 5 ; JCR ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

---