Journal Article

DZNE-2026-00254

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Cerebellar pathology contributes to neurodevelopmental deficits in spinal muscular atrophy.

Gerstner, F. ; Wittig, S. ; Menedo, C. ; Ruwald, S. ; Carlini, M. J. ; Vankova, A. ; Sowoidnich, L. ; Martín-López, G. ; Dreilich, V. ; Alonso-Collado, A. ; Pagiazitis, J. G. ; Aousji, O. ; Grzyb, C. ; Smith, A. K. ; Yang, M. ; Roselli, F.DZNE* ; Mentis, G. Z. ; Sumner, C. J. ; Pellizzoni, L. ; Simon, C. M.

2026
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/brain/awaf336

Abstract: Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by ubiquitous survival motor neuron (SMN) deficiency and loss of motor neurons. The persistence of motor and communication impairments, together with emerging cognitive and social deficits in severe type I SMA patients treated early with SMN-restoring therapies, suggests a broader dysfunction involving neural circuits of the brain. To explore the potential supraspinal contributions to these emerging phenotypes, we investigated the cerebellum, a brain region crucial for both motor and cognitive behaviours. Here, we identify cerebellar pathology in both post-mortem tissue from type I SMA patients and a severe mouse model, which is characterized by lobule-specific Purkinje cell death driven by cell-autonomous, non-apoptotic p53-dependent mechanisms. Loss and dysfunction of excitatory parallel fibre synapses onto Purkinje cells contribute further to cerebellar circuit disruption and altered Purkinje cell firing. Furthermore, we identified impaired ultrasonic vocalization (a proxy for early-developing social communication skills that depend on cerebellar function) in a severe SMA mouse model. Cell-specific rescue experiments demonstrate that intrinsic cerebellar pathology contributes to motor and social communication impairments independently of spinal motor circuit abnormalities. Together, these findings establish cerebellar dysfunction as a pathogenic driver of neurodevelopmental motor and social defects, providing mechanistic insight into the persisting and emerging phenotypes of SMA.

Keyword(s): Animals (MeSH) ; Mice (MeSH) ; Cerebellum: pathology (MeSH) ; Cerebellum: physiopathology (MeSH) ; Humans (MeSH) ; Purkinje Cells: pathology (MeSH) ; Male (MeSH) ; Disease Models, Animal (MeSH) ; Female (MeSH) ; Muscular Atrophy, Spinal: pathology (MeSH) ; Neurodevelopmental Disorders: pathology (MeSH) ; Neurodevelopmental Disorders: etiology (MeSH) ; Motor Neurons: pathology (MeSH) ; Mice, Inbred C57BL (MeSH) ; autism-like behaviour ; cerebellar circuit dysfunction ; motor neuron diseases ; neuronal death ; social deficits

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Contributing Institute(s):

1. Metabolic Changes in Neurodegeneration (AG Roselli)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 10 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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