Journal Article

DZNE-2026-00276

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Factors Contributing to Short-Term Structural Variability in a Longitudinal MRI Dataset.

Kalc, P. ; Ter Veer, M. ; Dahnke, R. ; Ziegler, G.DZNE* ; Kühn, S. ; Gaser, C.

2026
Wiley-Liss New York, NY

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Please use a persistent id in citations: doi:10.1002/hbm.70500

Abstract: When planning longitudinal magnetic resonance imaging (MRI) studies, it is advisable to consider various (confounding) factors that could influence brain structural changes over time. The goal of this study was to identify factors that contribute to intraindividual variability of brain structure within a short period of time. We employed multilevel sparse partial least squares regression to investigate the changes in regional gray matter volume in the longitudinal Day2day MRI dataset. The findings suggest that the changes in regional GM volume estimations were primarily driven by image quality, while the outdoor temperature and time since baseline appeared as the main predictors of volumetric changes in insular and diencephalic brain regions. We additionally investigated factors associated with variability in image quality. The findings underscore the importance of maintaining adequate participant arousal during scanning.

Keyword(s): Humans (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Magnetic Resonance Imaging: standards (MeSH) ; Male (MeSH) ; Longitudinal Studies (MeSH) ; Gray Matter: diagnostic imaging (MeSH) ; Gray Matter: anatomy & histology (MeSH) ; Female (MeSH) ; Adult (MeSH) ; Brain: diagnostic imaging (MeSH) ; Brain: anatomy & histology (MeSH) ; Young Adult (MeSH) ; Image Processing, Computer-Assisted (MeSH) ; Neuroimaging: standards (MeSH) ; longitudinal ; partial least squares ; structural MRI ; within‐subject variance

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Contributing Institute(s):

1. Clinical Neurophysiology and Memory (AG Düzel)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

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; ; Article Processing Charges ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DEAL Wiley ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; Fees ; IF < 5 ; JCR ; Nationallizenz ; PubMed Central ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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