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| Home > Publications Database > All-optical closed-loop control of human cardiomyocyte networks exploiting holographic optogenetics. |
| Journal Article | DZNE-2026-00982 |
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2026
Nature Publishing Group UK
[London]
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Please use a persistent id in citations: doi:10.1038/s44172-026-00779-1
Abstract: Heart diseases can trigger life-threatening arrhythmias by disrupting cardiac contraction wavefront propagation. In contrast to conventional treatments like electrical pacemakers, optogenetics offers high spatial and temporal resolution for non-invasive interrogation and modulation of cellular activity. However, combining sensing and actuation into a real-time control loop remains challenging. A major obstacle is the data load associated with dense sensor arrays typically required for spatially resolved wavefront monitoring. To overcome this, we present an all-optical, closed-loop control strategy using adaptive holographic stimulation and sparsely sampled, label-free imaging data, enabling robust classification and quantitative characterization of spatial wavefront properties in real time. We successfully demonstrate spatiotemporal optogenetic closed-loop control of wavefront dynamics in functional syncytia of human induced pluripotent stem cell-derived cardiomyocytes in at least 107 out of 109 evaluated cases across all experiments. This framework establishes a foundation for advanced feedback control strategies aimed at mimicking, detecting and terminating abnormal propagation patterns.
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