Journal Article

DZNE-2026-01163

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Impact of Respiratory Support Strategies on CO2 Variability During Therapeutic Hypothermia in Neonates With Asphyxia: Data From the German Hypothermia Registry.

Demir, S. ; Groteklaes, A. ; Bohnhorst, B. ; Glaser, K. ; Müller, A. ; Sabir, H.DZNE* ; Dresbach, T. ; Registry, G. H. (Collaboration Author) ; Brasche, M. (Contributor) ; Allgaier, N. (Contributor) ; Klotz, D. (Contributor) ; Teig, N. (Contributor) ; Schneider, K. (Contributor) ; Sabir, H. (Contributor)Extern* ; Holz, S. (Contributor) ; Tröger, B. (Contributor) ; Körner, T. (Contributor) ; Höpner, U. (Contributor) ; Schmenk, M. (Contributor) ; Hofmann, M. (Contributor)Extern* ; Rüdiger, M. (Contributor) ; Osterholt, J. (Contributor) ; Berghäuser, M. (Contributor) ; Willerscheidt, C. (Contributor) ; Morgenroth, F. (Contributor) ; Bittrich, H. J. (Contributor) ; Hébert, S. (Contributor) ; Arapi, A. (Contributor) ; Stein, A. (Contributor) ; Lange, V. (Contributor) ; Rau, G. (Contributor) ; Stoek, L.-M. (Contributor) ; Hillenbrand, N. (Contributor) ; Reger, M. (Contributor) ; Schade, S. (Contributor) ; Dieks, J. (Contributor) ; von Osten, H. (Contributor) ; Horstkemper, M. (Contributor) ; Blohm, M. (Contributor) ; Lange, M. (Contributor) ; Bohnhorst, B. (Contributor) ; Richter, M. F. (Contributor) ; Kranig, S. (Contributor) ; Petrasch, M. (Contributor) ; Nourkami-Tutdibi, N. (Contributor) ; Pinkwart, C. (Contributor) ; Kriebel, T. (Contributor) ; Welcker, S. (Contributor) ; Bonney, N. (Contributor) ; Kribs, A. (Contributor) ; Andrée, C. (Contributor) ; Stadermann, S. (Contributor) ; Glaser, K. (Contributor) ; Jahn, P. (Contributor) ; Braun, K. (Contributor) ; Eisenhardt, A. (Contributor) ; Perez-Ortiz, A. (Contributor) ; Mand, N. (Contributor) ; Wallot, I. (Contributor) ; Takacs, T. (Contributor) ; Jäger, A. (Contributor) ; Schroers, O. (Contributor) ; Schouten, E. (Contributor) ; Nussbaum, C. (Contributor) ; Böckenholt, K. (Contributor) ; Wentzell, R. (Contributor) ; Engelmann, G. (Contributor) ; Kastor, K. L. (Contributor) ; Schroth, M. (Contributor) ; Engler, M. (Contributor) ; Eichhorn, F. (Contributor) ; Rohrbach, M. (Contributor) ; Bärtling, F. (Contributor) ; Dohle, F. (Contributor) ; Keller, M. (Contributor) ; Weber, M. (Contributor) ; Lehnerer, V. (Contributor) ; Mayer, A. (Contributor) ; Detemple, M.-C. (Contributor) ; Oellers, V. (Contributor) ; Pingel, M. (Contributor) ; Eilbracht, F. (Contributor) ; Adler, J. (Contributor) ; Eberle, E. (Contributor) ; Goj, K. (Contributor) ; Toth, V. (Contributor) ; Czoske, A. (Contributor) ; Wiechers, C. (Contributor) ; Mayer, C. (Contributor) ; Schumann, A. (Contributor) ; Salaschek, P. (Contributor) ; Rauch, J. (Contributor) ; Hensel, K. (Contributor) ; Paul, P. (Contributor)

2026
Wiley-Blackwell Oxford

This record in other databases:    

Please use a persistent id in citations: doi:10.1111/apa.70702

Abstract: To evaluate associations between respiratory support strategies, partial pressure of carbon dioxide (pCO2) variability and oxygen exposure in neonates with hypoxic-ischaemic encephalopathy (HIE) undergoing therapeutic hypothermia (TH).This retrospective multicentre study used data from the German Hypothermia Registry, including neonates ≥ 36 weeks with moderate-to-severe HIE treated with TH between 2022 and 2025. Respiratory support was categorized as continuous positive airway pressure (CPAP) or invasive ventilation. Maximum and minimum pCO2 and fraction of inspired oxygen (FiO2) were analysed during the first 6 and 72 h of life.Among 428 neonates, 99% required respiratory support and 88% received invasive ventilation. Ventilated neonates showed higher maximum pCO2 levels than CPAP-supported neonates within the first 6 h (70 vs. 55 mmHg, p = 0.005) and over 72 h (70 vs. 60 mmHg, p < 0.001), while minimum pCO2 values were lower. Invasive ventilation was also associated with higher FiO2 requirements and longer oxygen supplementation (4 vs. 1 days, p < 0.001). In neonates with moderate HIE, CPAP was associated with shorter oxygen exposure, earlier oral feeding and reduced hospital stay.Respiratory support strategy during TH is associated with distinct patterns of CO2 and oxygen exposure. CPAP appears feasible in selected neonates with moderate HIE and favourable amplitude-integrated electroencephalography (aEEG) patterns.

Keyword(s): Humans (MeSH) ; Hypothermia, Induced (MeSH) ; Retrospective Studies (MeSH) ; Infant, Newborn (MeSH) ; Carbon Dioxide: blood (MeSH) ; Registries (MeSH) ; Hypoxia-Ischemia, Brain: therapy (MeSH) ; Hypoxia-Ischemia, Brain: blood (MeSH) ; Asphyxia Neonatorum: therapy (MeSH) ; Asphyxia Neonatorum: blood (MeSH) ; Asphyxia Neonatorum: complications (MeSH) ; Female (MeSH) ; Germany (MeSH) ; Male (MeSH) ; Continuous Positive Airway Pressure (MeSH) ; Respiration, Artificial: methods (MeSH) ; carbon dioxide ; hypoxic–ischaemic encephalopathy ; perinatal asphyxia ; respiratory support ; therapeutic hypothermia ; Carbon Dioxide

Note: ISSN 1651-2227 not unique: **2 hits**.

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Contributing Institute(s):

1. Neonatal Neuroscience (AG Sabir)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; DEAL Wiley ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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