Journal Article

DZNE-2020-03556

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png CRIS-a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending.

Krähling, A. M. ; Alvarez, L. ; Debowski, K. ; Van, Q. ; Gunkel, M. ; Irsen, S. ; Alamoudi, A.DZNE* ; Strünker, T. ; Kremmer, E. ; Krause, E. ; Voigt, I. ; Wörtge, S. ; Waisman, A. ; Weyand, I. ; Seifert, R. ; Kaupp, U. B. ; Wachten, D. (Corresponding author)

2013
Public Library of Science San Francisco, Calif.

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Please use a persistent id in citations: doi:10.1371/journal.pgen.1003960

Abstract: The second messengers cAMP and cGMP activate their target proteins by binding to a conserved cyclic nucleotide-binding domain (CNBD). Here, we identify and characterize an entirely novel CNBD-containing protein called CRIS (cyclic nucleotide receptor involved in sperm function) that is unrelated to any of the other members of this protein family. CRIS is exclusively expressed in sperm precursor cells. Cris-deficient male mice are either infertile due to a lack of sperm resulting from spermatogenic arrest, or subfertile due to impaired sperm motility. The motility defect is caused by altered Ca(2+) regulation of flagellar beat asymmetry, leading to a beating pattern that is reminiscent of sperm hyperactivation. Our results suggest that CRIS interacts during spermiogenesis with Ca(2+)-regulated proteins that--in mature sperm--are involved in flagellar bending.

Keyword(s): Animals (MeSH) ; Calcium: metabolism (MeSH) ; Carrier Proteins: genetics (MeSH) ; Cyclic AMP: genetics (MeSH) ; Cyclic AMP: metabolism (MeSH) ; Cyclic GMP: metabolism (MeSH) ; Flagella: genetics (MeSH) ; Flagella: metabolism (MeSH) ; Humans (MeSH) ; Intracellular Signaling Peptides and Proteins (MeSH) ; Male (MeSH) ; Mice (MeSH) ; Phosphorylation (MeSH) ; Protein Binding: genetics (MeSH) ; Signal Transduction: genetics (MeSH) ; Sperm Motility: genetics (MeSH) ; Spermatogenesis: genetics (MeSH) ; Spermatozoa: metabolism (MeSH) ; CRIS protein, mouse ; Carrier Proteins ; Intracellular Signaling Peptides and Proteins ; Cyclic AMP ; Cyclic GMP ; Calcium

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Contributing Institute(s):

1. Cryo-electron microscopy and tomography (AG Alamoudi)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2013

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