Journal Article

DZNE-2020-03819

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Coexpressed auxiliary subunits exhibit distinct modulatory profiles on AMPA receptor function.

Khodosevich, K. ; Jacobi, E.DZNE* ; Farrow, P.DZNE* ; Schulmann, A. ; Rusu, A. ; Zhang, L. ; Sprengel, R. ; Monyer, H. ; Engelhardt, J. (Last author)DZNE*

2014
Elsevier New York, NY

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Please use a persistent id in citations: doi:10.1016/j.neuron.2014.07.004

Abstract: Gating properties and surface trafficking of AMPA receptors (AMPARs) are modulated by auxiliary subunits. Here we studied the function of coexpressed auxiliary subunits belonging to two different classes. We focused on TARP γ-8 and CKAMP44 in dentate gyrus (DG) granule cells, since both subunits are highly expressed in this cell type. TARP γ-8 and CKAMP44 decrease the rate of deactivation but have an opposing influence on receptor desensitization, which accounts for their differential modulation of synaptic short-term plasticity. Furthermore, long-term plasticity (LTP) requires TARP γ-8 but not CKAMP44. The coexpression of both auxiliary subunits is necessary for the efficient targeting of AMPARs to the cell surface of DG granule cells. Finally, electrophysiological and biochemical evidence support the notion that CKAMP44 and TARP γ-8 can be contained in the same AMPAR complex.

Keyword(s): Animals (MeSH) ; Calcium Channels: metabolism (MeSH) ; Dentate Gyrus: metabolism (MeSH) ; Excitatory Postsynaptic Potentials: physiology (MeSH) ; Gene Knockout Techniques (MeSH) ; Humans (MeSH) ; Membrane Proteins: metabolism (MeSH) ; Mice (MeSH) ; Nerve Tissue Proteins: metabolism (MeSH) ; Neuronal Plasticity: genetics (MeSH) ; Neuronal Plasticity: physiology (MeSH) ; Neurons: metabolism (MeSH) ; Neurons: physiology (MeSH) ; Patch-Clamp Techniques: methods (MeSH) ; Receptors, AMPA: genetics (MeSH) ; Receptors, AMPA: metabolism (MeSH) ; Synapses: physiology (MeSH) ; Synaptic Transmission: physiology (MeSH) ; CKAMP44 protein, mouse ; Calcium Channels ; Membrane Proteins ; Nerve Tissue Proteins ; Receptors, AMPA ; TARP gamma-8 protein, mouse

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Contributing Institute(s):

1. Synaptic Signalling and Neurodegeneration (AG Engelhardt)

Research Program(s):

1. 341 - Molecular Signaling (POF3-341) (POF3-341)

Appears in the scientific report 2014

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 10 ; JCR ; NCBI Molecular Biology Database ; Nationallizenz ; SCOPUS ; Science Citation Index ; Science Citation Index Expanded ; Web of Science Core Collection

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