Journal Article

DZNE-2020-06230

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Every-other-day feeding extends lifespan but fails to delay many symptoms of aging in mice.

Xie, K. (First author)DZNE* ; Neff, F. ; Markert, A.DZNE* ; Rozman, J. ; Aguilar-Pimentel, J. A. ; Amarie, O. V. ; Becker, L. ; Brommage, R. ; Garrett, L. ; Henzel, K. S.DZNE* ; Hölter, S. M. ; Janik, D. ; Lehmann, I.DZNE* ; Moreth, K. ; Pearson, B. L.DZNE* ; Racz, I. ; Rathkolb, B. ; Ryan, D. P.DZNE* ; Schröder, S.DZNE* ; Treise, I. ; Bekeredjian, R. ; Busch, D. H. ; Graw, J. ; Ehninger, G. ; Klingenspor, M. ; Klopstock, T.DZNE* ; Ollert, M. ; Sandholzer, M. ; Schmidt-Weber, C. ; Weiergräber, M. ; Wolf, E. ; Wurst, W.DZNE* ; Zimmer, A. ; Gailus-Durner, V. ; Fuchs, H. ; Hrabě de Angelis, M. ; Ehninger, D. (Last author)DZNE*

2017
Nature Publishing Group UK [London]

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Please use a persistent id in citations: doi:10.1038/s41467-017-00178-3

Abstract: Dietary restriction regimes extend lifespan in various animal models. Here we show that longevity in male C57BL/6J mice subjected to every-other-day feeding is associated with a delayed onset of neoplastic disease that naturally limits lifespan in these animals. We compare more than 200 phenotypes in over 20 tissues in aged animals fed with a lifelong every-other-day feeding or ad libitum access to food diet to determine whether molecular, cellular, physiological and histopathological aging features develop more slowly in every-other-day feeding mice than in controls. We also analyze the effects of every-other-day feeding on young mice on shorter-term every-other-day feeding or ad libitum to account for possible aging-independent restriction effects. Our large-scale analysis reveals overall only limited evidence for a retardation of the aging rate in every-other-day feeding mice. The data indicate that every-other-day feeding-induced longevity is sufficiently explained by delays in life-limiting neoplastic disorders and is not associated with a more general slowing of the aging process in mice.Dietary restriction can extend the life of various model organisms. Here, Xie et al. show that intermittent periods of fasting achieved through every-other-day feeding protect mice against neoplastic disease but do not broadly delay organismal aging in animals.

Keyword(s): Aging (MeSH) ; Animals (MeSH) ; Food Deprivation (MeSH) ; Longevity (MeSH) ; Male (MeSH) ; Mice (MeSH) ; Mice, Inbred C57BL (MeSH)

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Contributing Institute(s):

1. Translational Biogerontology (AG Ehninger)
2. Animal Facility Bonn (Animal Facility Bonn)
3. Clinical Neurodegeneration (AG Levin)
4. Genome Engineering (AG Wurst)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)
2. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2017

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Database coverage:
; ; ; ; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Agriculture, Biology and Environmental Sciences ; Current Contents - Life Sciences ; Current Contents - Physical, Chemical and Earth Sciences ; DOAJ Seal ; IF >= 15 ; JCR ; SCOPUS ; Web of Science Core Collection ; Zoological Record

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