Journal Article (Review Article)

DZNE-2020-06810

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png The gut microbiome in Parkinson's disease | Das Darmmikrobiom bei der Parkinson-Krankheit

Bedarf, J. (First author)DZNE* ; Hildebrand, F. ; Goeser, F. ; Bork, P. ; Wüllner, U. (Last author)DZNE*

2019
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00115-018-0601-6

Abstract: The vast majority of Parkinson's disease (PD) cases are of sporadic origin and despite extensive research in recent years, the etiology still remains unclear. Several current case control studies are aiming to characterize a putative PD-specific composition of the gut microbiome, reflecting the potential relevance of microbiota in the pathogenesis of PD. Although methodologies and cohort sizes differed, the currently available studies showed reproducible or consistent results in terms of PD-specific alterations to the intestinal bacteria. By applying metagenomic sequencing procedures, it is even possible to distinguish PD cases from healthy individuals at a very early disease stage by means of individually modified microbiota. Among others, microbiota that are associated with an altered intestinal barrier or immune function, such as Akkermansia, Lactobacillus, Faecalibacterium and Prevotella were significantly over-represented or under-represented. There may even be a prodromal microbiome, as a comparable microbial shift is also found in patients with rapid eye movement (REM) sleep behavior disorder (RBD), a risk factor for the later development of synucleinopathies, such as PD.

Keyword(s): Case-Control Studies (MeSH) ; Gastrointestinal Microbiome (MeSH) ; Humans (MeSH) ; Metagenome (MeSH) ; Parkinson Disease: diagnosis (MeSH) ; Parkinson Disease: microbiology (MeSH) ; REM Sleep Behavior Disorder: microbiology (MeSH)

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Contributing Institute(s):

1. Prion and prion-like diseases (AG Tamgüney 2)
2. Biomarker Parkinson's Disease (AG Wüllner)

Research Program(s):

1. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)
2. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Ebsco Academic Search ; IF < 5 ; JCR ; SCOPUS ; Web of Science Core Collection

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