Journal Article

DZNE-2020-07825

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases.

Betts, M. J. (First author)DZNE* ; Kirilina, E. ; Otaduy, M. C. G. ; Ivanov, D. ; Acosta-Cabronero, J. ; Callaghan, M. F. ; Lambert, C. ; Cardenas-Blanco, A.DZNE* ; Pine, K. ; Passamonti, L. ; Loane, C. ; Keuken, M. C. ; Trujillo, P. ; Lüsebrink, F. ; Mattern, H. ; Liu, K. Y. ; Priovoulos, N. ; Fliessbach, K.DZNE* ; Dahl, M. J. ; Maaß, A.DZNE* ; Madelung, C. F. ; Meder, D. ; Ehrenberg, A. J. ; Speck, O.DZNE* ; Weiskopf, N. ; Dolan, R. ; Inglis, B. ; Tosun, D. ; Morawski, M. ; Zucca, F. A. ; Siebner, H. R. ; Mather, M. ; Uludag, K. ; Heinsen, H. ; Poser, B. A. ; Howard, R. ; Zecca, L. ; Rowe, J. B. ; Grinberg, L. T. ; Jacobs, H. I. L. ; Düzel, E.DZNE* ; Hämmerer, D.

2019
Oxford Univ. Press Oxford

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Please use a persistent id in citations: doi:10.1093/brain/awz193

Abstract: Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. Novel MRI approaches now provide an opportunity to quantify structural features of the locus coeruleus in vivo during disease progression. In combination with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand the contribution of locus coeruleus neurodegeneration to clinical and pathological manifestations in Alzheimer's disease, atypical neurodegenerative dementias and Parkinson's disease. Moreover, as the functional sensitivity of the noradrenergic system is likely to change with disease progression, in vivo measures of locus coeruleus integrity could provide new pathophysiological insights into cognitive and behavioural symptoms. Locus coeruleus imaging also holds the promise to stratify patients into clinical trials according to noradrenergic dysfunction. In this article, we present a consensus on how non-invasive in vivo assessment of locus coeruleus integrity can be used for clinical research in neurodegenerative diseases. We outline the next steps for in vivo, post-mortem and clinical studies that can lay the groundwork to evaluate the potential of locus coeruleus imaging as a biomarker for neurodegenerative diseases.

Keyword(s): Biomarkers: metabolism (MeSH) ; Humans (MeSH) ; Locus Coeruleus: diagnostic imaging (MeSH) ; Locus Coeruleus: metabolism (MeSH) ; Magnetic Resonance Imaging: methods (MeSH) ; Neurodegenerative Diseases: diagnostic imaging (MeSH) ; Neurodegenerative Diseases: metabolism (MeSH) ; Norepinephrine: metabolism (MeSH)

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Contributing Institute(s):

1. Linking imaging projects iNET (AG Speck)
2. Clinical Neurophysiology and Memory (AG Düzel)
3. Patient Studies Bonn (Patient Studies Bonn)

Research Program(s):

1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)

Appears in the scientific report 2019

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Database coverage:
; BIOSIS Previews ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; Current Contents - Life Sciences ; Ebsco Academic Search ; IF >= 15 ; JCR ; Nationallizenz ; SCOPUS ; Web of Science Core Collection

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