Journal Article DZNE-2020-00387

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Memorability of photographs in subjective cognitive decline and mild cognitive impairment: Implications for cognitive assessment.

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2019
Elsevier Amsterdam [u.a.]

Alzheimer's & dementia / Diagnosis, assessment & disease monitoring 11(1), 610-618 () [10.1016/j.dadm.2019.07.005]

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Abstract: Impaired long-term memory is a defining feature of mild cognitive impairment (MCI). We tested whether this impairment is item specific, limited to some memoranda, whereas some remain consistently memorable.We conducted item-based analyses of long-term visual recognition memory. Three hundred ninety-four participants (healthy controls, subjective cognitive decline [SCD], and MCI) in the multicentric DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE) were tested with images from a pool of 835 photographs.We observed consistent memorability for images in healthy controls, SCD, and MCI, predictable by a neural network trained on another healthy sample. Looking at memorability differences between groups, we identified images that could successfully categorize group membership with higher success and a substantial image reduction than the original image set.Individuals with SCD and MCI show consistent memorability for specific items, while other items show significant diagnosticity. Certain stimulus features could optimize diagnostic assessment, while others could support memory.

Classification:

Contributing Institute(s):
  1. Clinical Neurophysiology and Memory (AG Düzel)
  2. Neuroprotection (AG Müller)
  3. Patient Studies Bonn (Patient Studies Bonn)
  4. Neuroinflammation, Biomarker (AG Heneka ; AG Heneka)
  5. Translational Neurodegeneration (AG Höglinger 1)
  6. Cell Biology of Neurological Diseases (AG Jucker)
  7. Translational Neuropsychiatry (AG Priller)
  8. Clinical Dementia Research Bonn (Clinical Dementia Research Bonn)
  9. Clinical Dementia Research (Rostock /Greifswald) (AG Teipel)
  10. Molecular biomarkers for predictive diagnostics of neurodegenerative diseases (AG Wiltfang)
  11. Göttingen common (Göttingen common)
  12. Neuropsychology (AG Wagner)
  13. Clinical Alzheimer’s Disease Research (AG Jessen)
  14. Delcode (Delcode)
Research Program(s):
  1. 344 - Clinical and Health Care Research (POF3-344) (POF3-344)
  2. 342 - Disease Mechanisms and Model Systems (POF3-342) (POF3-342)
Experiment(s):
  1. Longitudinal Cognitive Impairment and Dementia Study

Appears in the scientific report 2019
Database coverage:
Medline ; Creative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0 ; DOAJ ; OpenAccess ; Clarivate Analytics Master Journal List ; DOAJ Seal ; Emerging Sources Citation Index ; SCOPUS ; Web of Science Core Collection
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The record appears in these collections:
Institute Collections > BN DZNE > BN DZNE-Patient Studies (Bonn)
Institute Collections > GÖ DZNE > GÖ DZNE-Göttingen common
Document types > Articles > Journal Article
Institute Collections > M DZNE > M DZNE-AG Höglinger 1
Institute Collections > GÖ DZNE > GÖ DZNE-AG Wiltfang
Institute Collections > BN DZNE > BN DZNE-AG Schneider
Institute Collections > ROS DZNE > ROS DZNE-AG Teipel
Institute Collections > TÜ DZNE > TÜ DZNE-AG Jucker
Institute Collections > MD DZNE > MD DZNE-AG Müller
Institute Collections > BN DZNE > BN DZNE-AG Jessen
Institute Collections > MD DZNE > MD DZNE-AG Düzel
Institute Collections > BN DZNE > BN DZNE-AG Wagner
Institute Collections > BN DZNE > BN DZNE-AG Heneka
Institute Collections > B DZNE > B DZNE-AG Priller
Institute Collections > M DZNE > M DZNE-Delcode
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 Record created 2020-07-14, last modified 2024-03-21


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