Journal Article

DZNE-2021-01539

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Transmission of trained immunity and heterologous resistance to infections across generations.

Katzmarski, N. ; Domínguez-Andrés, J. ; Cirovic, B. ; Renieris, G. ; Ciarlo, E. ; Le Roy, D. ; Lepikhov, K. ; Kattler, K. ; Gasparoni, G. ; Händler, K.DZNE* ; Theis, H.DZNE* ; Beyer, M.DZNE* ; van der Meer, J. W. M. ; Joosten, L. A. B. ; Walter, J. ; Schultze, J. L.DZNE* ; Roger, T. ; Giamarellos-Bourboulis, E. J. ; Schlitzer, A. ; Netea, M. G.

2021
Springer Nature Limited London

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Please use a persistent id in citations: doi:10.1038/s41590-021-01052-7

Abstract: Intergenerational inheritance of immune traits linked to epigenetic modifications has been demonstrated in plants and invertebrates. Here we provide evidence for transmission of trained immunity across generations to murine progeny that survived a sublethal systemic infection with Candida albicans or a zymosan challenge. The progeny of trained mice exhibited cellular, developmental, transcriptional and epigenetic changes associated with the bone marrow-resident myeloid effector and progenitor cell compartment. Moreover, the progeny of trained mice showed enhanced responsiveness to endotoxin challenge, alongside improved protection against systemic heterologous Escherichia coli and Listeria monocytogenes infections. Sperm DNA of parental male mice intravenously infected with the fungus C. albicans showed DNA methylation differences linked to immune gene loci. These results provide evidence for inheritance of trained immunity in mammals, enhancing protection against infections.

Keyword(s): Animals (MeSH) ; Candida albicans: immunology (MeSH) ; Candida albicans: pathogenicity (MeSH) ; Candidiasis: genetics (MeSH) ; Candidiasis: immunology (MeSH) ; Candidiasis: metabolism (MeSH) ; Candidiasis: microbiology (MeSH) ; Cells, Cultured (MeSH) ; DNA Methylation (MeSH) ; Disease Models, Animal (MeSH) ; Epigenesis, Genetic (MeSH) ; Escherichia coli: immunology (MeSH) ; Escherichia coli: pathogenicity (MeSH) ; Escherichia coli Infections: genetics (MeSH) ; Escherichia coli Infections: immunology (MeSH) ; Escherichia coli Infections: metabolism (MeSH) ; Escherichia coli Infections: microbiology (MeSH) ; Heredity (MeSH) ; Host-Pathogen Interactions (MeSH) ; Immunity, Innate: genetics (MeSH) ; Listeria monocytogenes: immunology (MeSH) ; Listeria monocytogenes: pathogenicity (MeSH) ; Listeriosis: genetics (MeSH) ; Listeriosis: immunology (MeSH) ; Listeriosis: metabolism (MeSH) ; Listeriosis: microbiology (MeSH) ; Male (MeSH) ; Mice, Transgenic (MeSH) ; Myeloid Cells: immunology (MeSH) ; Myeloid Cells: metabolism (MeSH) ; Myeloid Cells: microbiology (MeSH) ; Spermatozoa: immunology (MeSH) ; Spermatozoa: metabolism (MeSH) ; Transcription, Genetic (MeSH)

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Contributing Institute(s):

1. Platform for Single Cell Genomics and Epigenomics (Schultze - PRECISE)
2. Immunogenomics and Neurodegeneration (AG Beyer)
3. Platform for Single Cell Genomics and Epigenomics at DZNE & University of Bonn (R&D PRECISE)

Research Program(s):

1. 354 - Disease Prevention and Healthy Aging (POF4-354) (POF4-354)
2. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2021

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 30 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article (Erratum/Correction) Katzmarski, N. ; Domínguez-Andrés, J. ; Cirovic, B. ; Renieris, G. ; Ciarlo, E. ; Le Roy, D. ; Lepikhov, K. ; Kattler, K. ; Gasparoni, G. ; Händler, K.DZNE* ; Theis, H.DZNE* ; Beyer, M.DZNE* ; van der Meer, J. W. M. ; Joosten, L. A. B. ; Walter, J. ; Schultze, J. L.DZNE* ; Roger, T. ; Giamarellos-Bourboulis, E. J. ; Schlitzer, A.Extern* ; Netea, M. G.
Author Correction: Transmission of trained immunity and heterologous resistance to infections across generations.
Nature immunology 24(2), 371-372 (2023) [10.1038/s41590-023-01426-z]2023   Files BibTeX | EndNote: XML, Text | RIS

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