Journal Article

DZNE-2022-00509

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Möglicher Einfluss von Viren auf die Ausbreitung von Proteinaggregaten

Heumueller, S.-E. (First author)DZNE* ; Vorberg, I. M. (Last author)DZNE*

2022
Spektrum Heidelberg

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Please use a persistent id in citations: doi:10.1007/s12268-022-1730-9

Abstract: Neurodegenerative diseases are associated with misfolding of proteins into highly-ordered amyloid fibrils. These protein aggregates can be transmitted to other cells in which they induce aggregation of proteins of the same kind. Mechanisms of intercellular transfer include direct cell contact or transfer of aggregates within extracellular vesicles. Recent research suggests that viral proteins can increase the intercellular spreading of protein aggregation by promoting the required membrane interactions.

Note: (CC BY)

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Contributing Institute(s):

1. Prion Cell Biology (AG Vorberg)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2022

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Database coverage:
; ; ; DEAL Springer ; SCOPUS

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