Journal Article

DZNE-2022-00653

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Long-Term Cognitive Decline Related to the Motor Phenotype in Parkinson's Disease.

Michels, J. ; van der Wurp, H. ; Kalbe, E. ; Rehberg, S. ; Storch, A.DZNE* ; Linse, K.Extern* ; Schneider, C. ; Gräber, S.DZNE* ; Berg, D.DZNE* ; Dams, J. ; Balzer-Geldsetzer, M. ; Hilker-Roggendorf, R. ; Oberschmidt, C. ; Baudrexel, S. ; Witt, K. ; Schmidt, N. ; Deuschl, G.Extern* ; Mollenhauer, B.Extern* ; Trenkwalder, C. ; Liepelt-Scarfone, I.DZNE* ; Spottke, A.DZNE* ; Roeske, S.DZNE* ; Wüllner, U.DZNE* ; Wittchen, H.-U. ; Riedel, O. ; Kassubek, J.Extern* ; Dodel, R.Extern* ; Schulz, J. B. ; Costa, A. S. ; Reetz, K.

2022
IOS Press Amsterdam

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Please use a persistent id in citations: doi:10.3233/JPD-212787

Abstract: Parkinson's disease (PD) is associated with various non-motor symptoms, including cognitive deterioration.Here, we used data from the DEMPARK/LANDSCAPE cohort to describe the association between progression of cognitive profiles and the PD motor phenotypes: postural instability and gait disorder (PIGD), tremor-dominant (TR-D), and not-determined (ND).Demographic, clinical, and neuropsychological six-year longitudinal data of 711 PD-patients were included (age: M = 67.57; 67.4% males). We computed z-transformed composite scores for a priori defined cognitive domains. Analyses were controlled for age, gender, education, and disease duration. To minimize missing data and drop-outs, three-year follow-up data of 442 PD-patients was assessed with regard to the specific role of motor phenotype on cognitive decline using linear mixed modelling (age: M = 66.10; 68.6% males).Our study showed that in the course of the disease motor symptoms increased while MMSE and PANDA remained stable in all subgroups. After three-year follow-up, significant decline of overall cognitive performance for PIGD-patients were present and we found differences for motor phenotypes in attention (β= -0.08, SE = 0.003, p < 0.006) and memory functions showing that PIGD-patients deteriorate per months by -0.006 compared to the ND-group (SE = 0.003, p = 0.046). Furthermore, PIGD-patients experienced more often difficulties in daily living.Over a period of three years, we identified distinct neuropsychological progression patterns with respect to different PD motor phenotypes, with early executive deficits yielding to a more amnestic profile in the later course. Here, in particular PIGD-patients worsened over time compared to TR-D and ND-patients, highlighting the greater risk of dementia for this motor phenotype.

Keyword(s): Cognitive Dysfunction: complications (MeSH) ; Female (MeSH) ; Gait Disorders, Neurologic: diagnosis (MeSH) ; Humans (MeSH) ; Male (MeSH) ; Neuropsychological Tests (MeSH) ; Parkinson Disease: diagnosis (MeSH) ; Phenotype (MeSH) ; Postural Balance (MeSH) ; Tremor: diagnosis (MeSH) ; Cognitive decline ; Parkinson’s disease ; dementia ; longitudinal ; mild cognitive impairment ; postural instability and gait disorder ; progression ; tremor-dominant

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Contributing Institute(s):

1. Non-Motor Symptoms in Parkinson's disease (AG Storch)
2. Core ICRU (Core ICRU)
3. Cell Biology of Neurological Diseases (AG Jucker)
4. Parkinson's Disease Genetics (AG Berg ; AG Berg)
5. Patient Studies (AG Klockgether)
6. Neuropsychology (AG Wagner)
7. Biomarker Parkinson's Disease (AG Wüllner)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)
2. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2022

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Database coverage:
; Clarivate Analytics Master Journal List ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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