Journal Article (Review Article)

DZNE-2022-00684

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Manifestationen im Zentralnervensystem nach COVID-19.

Gerhard, A. ; Prüß, H.DZNE* ; Franke, C.Extern*

2022
Springer Heidelberg

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Please use a persistent id in citations: doi:10.1007/s00115-022-01294-2

Abstract: Numerous diseases of the central nervous system (CNS), especially in the postacute phase after an infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been described. These include neuroimmunologically mediated diseases, such as encephalopathy, encephalitis, myelitis, acute disseminated encephalomyelitis (ADEM), acute necrotizing hemorrhagic leukoencephalitis (ANHLE) and neuromyelitis optica spectrum disorder (NMOSD) as well as others, such as posterior reversible encephalopathy syndrome (PRES), opsoclonus myoclonus ataxia (OMA) and cerebrovascular diseases. A parainfectious or postinfectious association is discussed but the pathophysiological mechanisms are so far unknown. Underlying mechanisms could be a virus-triggered overactivation of the immune system with hyperinflammation and cytokine storm but possibly also the development of specific autoantibodies against CNS tissue. Direct damage due to the invasion of SARS-CoV‑2 into the brain or spinal cord does not seem to play a relevant role. An exact clinical phenotyping and initiation of additional diagnostics are recommended, also to rule out other causes. To date no medicinal treatment options for CNS manifestations of long COVID exist; however, first results regarding inflammation and autoimmunity are promising and could lead to new treatment approaches.

Keyword(s): COVID-19: complications (MeSH) ; Central Nervous System (MeSH) ; Humans (MeSH) ; Nervous System Diseases: etiology (MeSH) ; Posterior Leukoencephalopathy Syndrome (MeSH) ; SARS-CoV-2 (MeSH) ; Post-Acute COVID-19 Syndrome (MeSH) ; Autoantibodies ; Encephalitis ; Hyperinflammation ; Immunotherapy ; Myelitis

Note: CC BY: https://creativecommons.org/licenses/by/4.0/

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Contributing Institute(s):

1. Autoimmune Enzephalopathies (AG Prüß)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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Database coverage:
; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DEAL Springer ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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