Journal Article (Review Article)

DZNE-2022-01346

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Moving through the crowd. Where are we at understanding physiological axon growth?

Alfadil, E. (First author)DZNE* ; Bradke, F. (Last author)DZNE*

2023
Academic Press London

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Please use a persistent id in citations: doi:10.1016/j.semcdb.2022.07.001

Abstract: Axon growth enables the rapid wiring of the central nervous system. Understanding this process is a prerequisite to retriggering it under pathological conditions, such as a spinal cord injury, to elicit axon regeneration. The last decades saw progress in understanding the mechanisms underlying axon growth. Most of these studies employed cultured neurons grown on flat surfaces. Only recently studies on axon growth were performed in 3D. In these studies, physiological environments exposed more complex and dynamic aspects of axon development. Here, we describe current views on axon growth and highlight gaps in our knowledge. We discuss how axons interact with the extracellular matrix during development and the role of the growth cone and its cytoskeleton within. Finally, we propose that the time is ripe to study axon growth in a more physiological setting. This will help us uncover the physiologically relevant mechanisms underlying axon growth, and how they can be reactivated to induce axon regeneration.

Keyword(s): Axons: physiology (MeSH) ; Nerve Regeneration (MeSH) ; Neurons (MeSH) ; Central Nervous System (MeSH) ; Neurogenesis: physiology (MeSH) ; Growth Cones (MeSH) ; Axon growth ; Cytoskeleton ; Growth cone ; Neuronal polarisation

Note: CC BY

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Contributing Institute(s):

1. Axon Growth and Regeneration (AG Bradke)

Research Program(s):

1. 351 - Brain Function (POF4-351) (POF4-351)

Appears in the scientific report 2023

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; ; ; BIOSIS Previews ; BIOSIS Reviews Reports And Meetings ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF >= 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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