Journal Article

DZNE-2022-01425

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Investigation of the functional pathogenesis of mild cognitive impairment by localisation‐based locus coeruleus resting‐state fMRI

Liebe, T. ; Dordevic, M.Extern* ; Kaufmann, J. ; Avetisyan, A.DZNE* ; Skalej, M. ; Müller, N.Extern*

2022
Wiley-Liss New York, NY

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Please use a persistent id in citations: doi:10.1002/hbm.26039

Abstract: Dementia as one of the most prevalent diseases urges for a better understanding of the central mechanisms responsible for clinical symptoms, and necessitates improvement of actual diagnostic capabilities. The brainstem nucleus locus coeruleus (LC) is a promising target for early diagnosis because of its early structural alterations and its relationship to the functional disturbances in the patients. In this study, we applied our improved method of localisation-based LC resting-state fMRI to investigate the differences in central sensory signal processing when comparing functional connectivity (fc) of a patient group with mild cognitive impairment (MCI, n = 28) and an age-matched healthy control group (n = 29). MCI and control participants could be differentiated in their Mini-Mental-State-Examination (MMSE) scores (p < .001) and LC intensity ratio (p = .010). In the fMRI, LC fc to anterior cingulate cortex (FDR p < .001) and left anterior insula (FDR p = .012) was elevated, and LC fc to right temporoparietal junction (rTPJ, FDR p = .012) and posterior cingulate cortex (PCC, FDR p = .021) was decreased in the patient group. Importantly, LC to rTPJ connectivity was also positively correlated to MMSE scores in MCI patients (p = .017). Furthermore, we found a hyperactivation of the left-insula salience network in the MCI patients. Our results and our proposed disease model shed new light on the functional pathogenesis of MCI by directing to attentional network disturbances, which could aid new therapeutic strategies and provide a marker for diagnosis and prediction of disease progression.

Keyword(s): Humans (MeSH) ; Locus Coeruleus: diagnostic imaging (MeSH) ; Magnetic Resonance Imaging (MeSH) ; Cognitive Dysfunction: diagnostic imaging (MeSH) ; Gyrus Cinguli (MeSH) ; Brain Stem (MeSH) ; attention ; locus coeruleus ; mild cognitive impairment ; resting-state fMRI

Note: CC BY-NC-ND: https://creativecommons.org/licenses/by-nc-nd/4.0/

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Contributing Institute(s):

1. Neuroprotection (AG Müller)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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