Journal Article

DZNE-2022-01571

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Fatigue and cognitive impairment after COVID-19: A prospective multicentre study.

Hartung, T. J. ; Neumann, C. ; Bahmer, T. ; Chaplinskaya-Sobol, I. ; Endres, M.DZNE* ; Geritz, J. ; Haeusler, K. G. ; Heuschmann, P. U. ; Hildesheim, H. ; Hinz, A. ; Hopff, S. ; Horn, A. ; Krawczak, M. ; Krist, L. ; Kudelka, J. ; Lieb, W. ; Maetzler, C.Extern* ; Mehnert-Theuerkauf, A. ; Montellano, F. A. ; Morbach, C. ; Schmidt, S. ; Schreiber, S.Extern* ; Steigerwald, F. ; Störk, S. ; Maetzler, W.Extern* ; Finke, C.Extern*

2022
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.eclinm.2022.101651

Abstract: Reliable estimates of frequency, severity and associated factors of both fatigue and cognitive impairment after COVID-19 are needed. Also, it is not clear whether the two are distinct sequelae of COVID-19 or part of the same syndrome.'In this prospective multicentre study, frequency of post-COVID fatigue and cognitive impairment were assessed in n = 969 patients (535 [55%] female) ≥6 months after SARS-CoV-2 infection with the FACIT-Fatigue scale (cut-off ≤30) and Montreal Cognitive Assessment (≤25 mild, ≤17 moderate impairment) between November 15, 2020 and September 29, 2021 at University Medical Center Schleswig-Holstein, Campus Kiel and University Hospital Würzburg in Germany. 969 matched non-COVID controls were drawn from a pre-pandemic, randomised, Germany-wide population survey which also included the FACIT-Fatigue scale. Associated sociodemographic, comorbid, clinical, psychosocial factors and laboratory markers were identified with univariate and multivariable linear regression models.On average 9 months after infection, 19% of patients had clinically relevant fatigue, compared to 8% of matched non-COVID controls (p < 0.001). Factors associated with fatigue were female gender, younger age, history of depression and the number of acute COVID symptoms. Among acute COVID symptoms, altered consciousness, dizziness and myalgia were most strongly associated with long-term fatigue. Moreover, 26% of patients had mild and 1% had moderate cognitive impairment. Factors associated with cognitive impairment were older age, male gender, shorter education and a history of neuropsychiatric disease. There was no significant correlation between fatigue and cognitive impairment and only 5% of patients suffered from both conditions.Fatigue and cognitive impairment are two common, but distinct sequelae of COVID-19 with potentially separate pathophysiological pathways.German Federal Ministry of Education and Research (BMBF).

Keyword(s): CI, confidence interval ; COVID-19 ; COVID-19, Coronavirus Disease 2019 ; CRP, C-reactive protein ; CSF, cerebrospinal fluid ; Cognitive dysfunction ; Fatigue ; GAD-7, 7-item anxiety screening questionnaire ; MoCA, Montreal Cognitive Assessment ; NAPKON, National Pandemic Cohort Network ; PCR, polymerase chain reaction ; PHQ-8, 8-item depression module of the Patient Health Questionnaire ; PSQI, Pittsburgh Sleep Quality Index ; Post-acute COVID-19 syndrome ; SARS-CoV-2 ; SARS-CoV-2, Severe Acute Respiratory Distress Syndrome caused by Corona Virus 2 ; VIF, variance inflation factor

Note: CC BY: https://creativecommons.org/licenses/by/4.0/

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Contributing Institute(s):

1. Coordinator of Clinical Research (AG Endres)

Research Program(s):

1. 353 - Clinical and Health Care Research (POF4-353) (POF4-353)

Appears in the scientific report 2022

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Database coverage:
; ; ; ; Article Processing Charges ; Clarivate Analytics Master Journal List ; Current Contents - Clinical Medicine ; DOAJ Seal ; Fees ; IF >= 15 ; JCR ; SCOPUS ; Web of Science Core Collection

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