Journal Article

DZNE-2023-00070

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Adolescent raloxifene treatment in females prevents cognitive deficits in a neurodevelopmental rodent model of schizophrenia.

Felgel-Farnholz, V. ; Hlusicka, E. B. ; Edemann-Callesen, H. ; Garthe, A.DZNE* ; Winter, C. ; Hadar, R.

2023
Elsevier Amsterdam

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Please use a persistent id in citations: doi:10.1016/j.bbr.2022.114276

Abstract: The existence of sex differences in schizophrenia is a well documented phenomenon which led to the hypothesis that female sex hormones are neuroprotective and hence responsible for the more favorable disease characteristics seen in women. The current study sought to investigate the effects of estrogen-like agents administered during early adolescence on behavioral outcomes in adulthood using the neurodevelopmental maternal immune activation (MIA) rodent model of schizophrenia. Female MIA offspring were administered during the asymptomatic period of adolescence with either 17β-estradiol, raloxifene or saline and were tested in late adolescence and adulthood for schizophrenia-related behavioral performance. We report here that whereas adult female MIA offspring exhibited cognitive deficits in the form of retarded spatial learning, the administration of raloxifene during adolescence was sufficient in preventing these deficits and resulted in intact performance in the MIA group.

Keyword(s): Animals (MeSH) ; Humans (MeSH) ; Female (MeSH) ; Male (MeSH) ; Raloxifene Hydrochloride: pharmacology (MeSH) ; Schizophrenia: complications (MeSH) ; Schizophrenia: drug therapy (MeSH) ; Rodentia (MeSH) ; Poly I-C: pharmacology (MeSH) ; Behavior, Animal: physiology (MeSH) ; Disease Models, Animal (MeSH) ; Prenatal Exposure Delayed Effects (MeSH) ; Cognition (MeSH) ; Raloxifene Hydrochloride ; Morris Water Maze (MWM) ; Poly I:C ; Preventive hormonal treatment ; Raloxifene ; estradiol ; schizophrenia ; Poly I-C

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Contributing Institute(s):

1. Technology Platform Neurobiology of Behaviour (AG Garthe)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2023

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Database coverage:
; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection

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