Dataset

DZNE-2023-00186

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset: Cerebrospinal Fluid (CSF) Proteomics of A30P-αS mice

Müller, S. A.DZNE* ; Lichtenthaler, S.DZNE*

2022
PRoteomics IDEntifications Database

Abstract: Here, we took advantage of well-defined mouse models for α-synucleinopathy (A30P-αS ) to explore proteome changes in the cerebrospinal fluid which are related to these distinct proteopathic lesions. Non-targeted liquid chromatography-mass spectrometry revealed that the majority of proteins that undergo age- and disease-related changes in either mouse model was linked to microglia, and more specifically to previously described disease state-specific microglia transcriptomic signatures. The finding that such transcriptomic changes translate into corresponding protein changes in cerebrospinal fluid is of high clinical relevance, supporting efforts to identify bodily fluid biomarkers that reflect the various functional states of microglial activation in Parkinson’s disease.

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Contributing Institute(s):

1. Neuroproteomics (AG Lichtenthaler)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2022

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Eninger, T. (First author)DZNE* ; Müller, S. A.DZNE* ; Bacioglu, M.DZNE* ; Schweighauser, M.DZNE* ; Lambert, M.DZNE* ; Maia, L. F.Extern* ; Neher, J.DZNE* ; Hornfeck, S. M.DZNE* ; Obermüller, U.DZNE* ; Kleinberger, G.Extern* ; Haass, C.DZNE* ; Kahle, P.DZNE* ; Staufenbiel, M.DZNE* ; Ping, L. ; Duong, D. M. ; Levey, A. I. ; Seyfried, N. T. ; Lichtenthaler, S.DZNE* ; Jucker, M.DZNE* ; Kaeser, S. A. (Last author)DZNE*
Signatures of glial activity can be detected in the CSF proteome
Proceedings of the National Academy of Sciences of the United States of America 119(24), e2119804119 (2022) [10.1073/pnas.2119804119]2022   Files  Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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