Dataset

DZNE-2023-00188

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Dataset: Mapping of TDP-43 ubiquitination and acetylation sites

Gloeckner, C. J. (Corresponding author)DZNE*

2022
PRoteomics IDEntifications Database

Abstract: TAR DNA binding protein of 43 kDa (TDP-43) forms aggregates in neurodegenerative diseases, particularly certain forms of frontotemporal dementia and amyotrophic lateral sclerosis. Pathological modifications of TDP-43 include proteolytic fragmentation, phosphorylation, and ubiquitinylation. In this study, we systematically mapped TDP-42 ubiquitination as well as acetylation sites.

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Contributing Institute(s):

1. Functional Neuroproteomics and Translational Biomarkers in Neurodegenerative Diseases (AG Gloeckner)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2022

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Linked articles:

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Hans, F. (First author)DZNE* ; Eckert, M.DZNE* ; von Zweydorf, F.DZNE* ; Gloeckner, C. J.DZNE* ; Kahle, P. J. (Last author)DZNE*
Identification and characterization of ubiquitinylation sites in TAR DNA-binding protein of 43 kDa (TDP-43).
The journal of biological chemistry 293(41), 16083-16099 (2018) [10.1074/jbc.RA118.003440]2018   Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Journal Article Garcia Morato, J. (First author)DZNE* ; Hans, F.DZNE* ; von Zweydorf, F.DZNE* ; Feederle, R.DZNE* ; Elsässer, S. J. ; Skodras, A.Extern* ; Gloeckner, C. J.DZNE* ; Buratti, E. ; Neumann, M.DZNE* ; Kahle, P. (Last author)DZNE*
Sirtuin-1 sensitive lysine-136 acetylation drives phase separation and pathological aggregation of TDP-43.
Nature Communications 13(1), 1223 (2022) [10.1038/s41467-022-28822-7]2022   Files  Fulltext by Pubmed Central BibTeX | EndNote: XML, Text | RIS

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