Journal Article (Review Article)

DZNE-2023-00196

http://join2-wiki.gsi.de/foswiki/pub/Main/Artwork/join2_logo100x88.png Biomolecular condensation involving the cytoskeleton.

Mohapatra, S. (First author)DZNE* ; Wegmann, S. (Last author)DZNE*

2023
Elsevier Science Amsterdam [u.a.]

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Please use a persistent id in citations: doi:10.1016/j.brainresbull.2023.01.009

Abstract: Biomolecular condensation of proteins contributes to the organization of the cytoplasm and nucleoplasm. A number of condensation processes appear to be directly involved in regulating the structure, function and dynamics of the cytoskeleton. Liquid-liquid phase separation of cytoskeleton proteins, together with polymerization modulators, promotes cytoskeletal fiber nucleation and branching. Furthermore, the attachment of protein condensates to the cytoskeleton can contribute to cytoskeleton stability and organization, regulate transport, create patterns of functional reaction containers, and connect the cytoskeleton with membranes. Surface-bound condensates can exert and buffer mechanical forces that give stability and flexibility to the cytoskeleton, thus, may play a large role in cell biology. In this review, we introduce the concept and role of cellular biomolecular condensation, explain its special function on cytoskeletal fiber surfaces, and point out potential definition and experimental caveats. We review the current literature on protein condensation processes related to the actin, tubulin, and intermediate filament cytoskeleton, and discuss some of them in the context of neurobiology. In summary, we provide an overview about biomolecular condensation in relation to cytoskeleton structure and function, which offers a base for the exploration and interpretation of cytoskeletal condensates in neurobiology.

Keyword(s): Cytoskeleton: metabolism (MeSH) ; Microtubules: metabolism (MeSH) ; Cytoskeletal Proteins (MeSH) ; Actins: metabolism (MeSH) ; Cytoplasm: metabolism (MeSH) ; Actin Cytoskeleton: metabolism (MeSH) ; Cytoskeletal Proteins ; Actin ; Condensation ; Cytoskeleton ; Intermediate filaments ; Liquid-liquid phase separation ; Microtubules ; Actins

Note: LIC: CCBYNCND4

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Contributing Institute(s):

1. Protein Actions in Neurodegeneration (AG Wegmann)

Research Program(s):

1. 352 - Disease Mechanisms (POF4-352) (POF4-352)

Appears in the scientific report 2023

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Database coverage:
; ; ; ; BIOSIS Previews ; Biological Abstracts ; Clarivate Analytics Master Journal List ; Current Contents - Life Sciences ; DOAJ Seal ; Ebsco Academic Search ; Essential Science Indicators ; IF < 5 ; JCR ; Nationallizenz ; SCOPUS ; Science Citation Index Expanded ; Web of Science Core Collection ; Zoological Record

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